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SH3PXD2B
SH3 and PX domains 2B
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
| Gene Name: | SH3 and PX domains 2B |
| Synonyms: | SH3PXD2B, Adapter protein HOFI, Adaptor protein HOFI, HOFI, FTHS, KIAA1295, TKS4, FAD49, SH3 and PX domains 2B, TSK4 |
| Target Sequences: | A1X283 A1X283 |
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