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SH3PXD2A / TKS5
SH3 and PX domains 2A
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
| Gene Name: | SH3 and PX domains 2A |
| Synonyms: | SH3PXD2A, Adapter protein TKS5, Adaptor protein TKS5, FISH, KIAA0418, SH3 and PX domains 2A, SH3 multiple domains protein 1, TSK5, SH3 multiple domains 1, SH3MD1, TKS5 |
| Target Sequences: | AX695698 IPI00023692.1 Q5TCZ1 |
Publications (2)
1
Identification of invadopodia by TKS5 staining in human cancer lines and patient tumor samples. Baik M, French B, Chen YC, Byers JT, Chen KT, French SW, Díaz B. MethodsX. 2019 March;6:718-726. [Full Text Article]
[PubMed:31011543]
[PMC:PMC6461573]
Related Antibodies: LS-C383498.
2
TKS5-positive invadopodia-like structures in human tumor surgical specimens. Yu-Chuan Chen, Matthew Baik, Joshua T Byers, Kathryn T Chen, Samuel W French, Begoña Díaz. Experimental and molecular pathology. 2019 February;106:17-26. [Full Text Article]
[PubMed:30439350]
[PMC:PMC6368464]
Related Antibodies: LS-C383498.
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Products
Antibodies
(16)
Proteins
(3)
Type
Over-Expression Lysate
(2)
Primary
(16)
Recombinant
(1)
Target
SH3PXD2A / TKS5
(19)
Reactivity
Human
(16)
Mouse
(3)
Rat
(1)
Application
IHC
(2)
WB
(15)
ELISA
(8)
IF
(1)
Peptide-ELISA
(1)
Host
rabbit
(10)
mouse
(6)
Isotype
IgG
(9)
IgG1
(4)
IgG2b
(2)
Clonality
monoclonal mc
(6)
polyclonal pc
(10)
Clone
OTI1F5
(2)
OTI1H9
(2)
OTI4B8
(2)
Format
APC Conjugated
(1)
Azide-free
(1)
Biotin Conjugated
(1)
Carrier-free
(3)
FITC Conjugated
(1)
HRP Conjugated
(1)
PE Conjugated
(1)
Unconjugated
(11)
Epitope
aa222-250
(7)
aa299-395
(6)
N-Terminal
(1)
Publications
No
(18)
Yes
(1)
Tag
10His, N-terminus + Myc, C-terminus
(1)
Myc-DDK (Flag)
(2)
Species
Human
(2)
Source
293T Cells
(1)
E. coli
(1)
HEK 293 Cells
(1)
Purification
Purified
(1)
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal (aa222-250) Antibody
Human
WB
Unconjugated
400 µl/$393
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal (aa222-250) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal (aa222-250) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal (aa222-250) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal (aa222-250) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal (aa222-250) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal (aa222-250) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
SH3PXD2A / TKS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SH3PXD2A / TKS5 Mouse anti-Human Monoclonal (aa299-395) (OTI1H9) Antibody
Human
WB
Unconjugated
100 µl/$434
SH3PXD2A / TKS5 Mouse anti-Human Monoclonal (aa299-395) (Carrier-free) (OTI1H9) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
SH3PXD2A / TKS5 Mouse anti-Human Monoclonal (aa299-395) (OTI4B8) Antibody
Human
WB
Unconjugated
100 µl/$434
SH3PXD2A / TKS5 Mouse anti-Human Monoclonal (aa299-395) (Carrier-free) (OTI4B8) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
SH3PXD2A / TKS5 Mouse anti-Human Monoclonal (aa299-395) (OTI1F5) Antibody
Human
WB
Unconjugated
100 µl/$434
SH3PXD2A / TKS5 Mouse anti-Human Monoclonal (aa299-395) (Carrier-free) (OTI1F5) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
E. coli
10His, N-terminus + Myc, C-terminus
14.0 kDa
20 µg/$364; 1 mg/$1,679; 100 µg/$500
HEK 293 Cells
Myc-DDK (Flag)
121.7 kDa
100 µg/$710
293T Cells
Myc-DDK (Flag)
121.7 kDa
20 µg/$215
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