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Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.
Gene Name: | SH2B adaptor protein 2 |
Synonyms: | SH2B2, APS, SH2B adapter protein 2, SH2B adaptor protein 2 |
Target Sequences: | NM_020979 |
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