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SFTPC / Surfactant Protein C

surfactant protein C

SFTPC / Surfactant Protein C is the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

Gene Name: surfactant protein C
Synonyms: SFTPC, BRICD6, PSP-C, Pulmonary surfactant protein C, SMDP2, SFTP2, SP-C, Surfactant protein C
Target Sequences: NM_003018 NP_003009.2 P11686

Publications (5)

1
Optimization of Variable Ventilation for Physiology, Immune Response and Surfactant Enhancement in Preterm Lambs. Bartolák-Suki E, Noble PB, Bou Jawde S, Pillow JJ, Suki B. Frontiers in physiology. 2017 8:425. (WB; Human) [Full Text Article] [PubMed:28690548] [PMC:PMC5481362]
2
Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. Yina Du, Geremy C Clair, Denise Al Alam, Soula Danopoulos, Daniel Schnell, Joseph A Kitzmiller, Ravi S Misra, Soumyaroop Bhattacharya, David Warburton, Thomas J Mariani, Gloria S Pryhuber, Jeffrey A Whitsett, Charles Ansong, Yan Xu. American journal of physiology. Lung cellular and molecular physiology. 2019 September;317:L347-L360. [Full Text Article] [PubMed:31268347] [PMC:PMC6766718] Related Antibodies: LS-B10952.
3
Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Sandra L Leibel, Rachael N McVicar, Alicia M Winquist, Walter D Niles, Evan Y Snyder. Current protocols in stem cell biology. 2020 September;54:e118. [Full Text Article] [PubMed:32640120] [PMC:PMC7361156] Related Antibodies: LS-B9161.
4
Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia10<sup> University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Pathology, Cologne, Germany12<sup> Dept of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany14<sup> University of Cologne, Faculty of Medicine and University Hospital Cologne, Translation. Dharmesh Hirani , Cristina M Alvira, Soula Danopoulos, Carlos Milla, Michele Donato, Lu Tian, Jasmine Mohr , Katharina Dinger , Christina Vohlen , Jaco Selle, Silke V Koningsbruggen-Rietschel, Verena Barbarino, Christian Pallasch, Stefan Rose-John, Margarete Odenthal, Gloria S Pryhuber, Siavash Mansouri, Rajkumar Savai , Werner Seeger , Purvesh Khatri, Denise Al Alam, Jörg Dötsch, Miguel A Alejandre Alcazar. The European respiratory journal. 2022 Feb;59:2002248. [Full Text Article] [PubMed:34446466] [PMC:PMC8850688] Related Antibodies: LS-B10952.
5
Hedgehog-responsive PDGFRa(+) fibroblasts maintain a unique pool of alveolar epithelial progenitor cells during alveologenesis. Feng Gao, Changgong Li, Soula Danopoulos, Denise Al Alam, Neil Peinado, Sha Webster, Zea Borok, GoleNaz Adeli Kohbodi, Saverio Bellusci, Parviz Minoo. Cell reports. 2022 April;39:110608. [Full Text Article] [PubMed:35385750] [PMC:PMC9199394] Related Antibodies: LS-B10952.
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SFTPC / Surfactant Protein C (100)
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SFTPC / Surfactant Protein C Antibody - Anti-SFTPC / Surfactant Protein C antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$460
SFTPC / Surfactant Protein C Antibody - Human, Lung, Type 2 pneumocytes: Formalin-Fixed Paraffin-Embedded (FFPE)
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (aa144-173) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
SFTPC / Surfactant Protein C Antibody - Immunohistochemistry of paraffin-embedded rat heart.
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (aa1-33) Antibody
Mouse, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$589
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Lung Lavage Fluid, Plasma, Serum, Tissue Homogenates
1 Plate/$798
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.469 - 30 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
SFTPC / Surfactant Protein C Antibody - Western blot analysis of extracts of various cell lines, using SFTPC Antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SFTPC / Surfactant Protein C Protein - Purified recombinant protein SFTPC was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.8 kDa
20 µg/$1,107
SFTPC / Surfactant Protein C Antibody - Detection limit for recombinant GST tagged SFTPC is 0.3 ng/ml as a capture antibody.
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SFTPC / Surfactant Protein C Mouse anti-Human Monoclonal (4A10) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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SFTPC / Surfactant Protein C Rabbit anti-Mouse Polyclonal (aa1-30) (FITC) Antibody
Mouse
ELISA, ICC, IF, WB
FITC Conjugated
200 µl/$952
SFTPC / Surfactant Protein C Protein - Recombinant Surfactant Associated Protein C By SDS-PAGE
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E. coli
His,N-terminus + GST
51.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
SFTPC / Surfactant Protein C Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
100 µg/$420; 1 mg/$1,355; 20 µg/$323
SFTPC / Surfactant Protein C Antibody - Western blot using SFTPC monoclonal antibody against human SFTPC recombinant protein. (Expected MW is 38.4 kDa)
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SFTPC / Surfactant Protein C Mouse anti-Human Monoclonal (5E6A9) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$459
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC
HRP Conjugated
50 µg/$294; 100 µg/$360
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
50 µg/$294; 100 µg/$360
SFTPC / Surfactant Protein C Antibody - Western blot of SFTPC / Surfactant Protein C antibody.
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (aa24-197) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
SFTPC / Surfactant Protein C Antibody - Western blot of SFTPC / Surfactant Protein C antibody.
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (aa24-197) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
SFTPC / Surfactant Protein C Antibody - Western Blot; Sample: Recombinant SPC, Mouse.
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SFTPC / Surfactant Protein C Rabbit anti-Mouse Polyclonal (aa94-193) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
SFTPC / Surfactant Protein C Antibody - Western Blot; Sample: Recombinant SPC, Mouse.
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SFTPC / Surfactant Protein C Rabbit anti-Mouse Polyclonal (aa94-193) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
SFTPC / Surfactant Protein C Antibody - Western blot of SFTPC / Surfactant Protein C antibody.
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SFTPC / Surfactant Protein C Rabbit anti-Mouse Polyclonal (aa1-193) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
SFTPC / Surfactant Protein C Antibody
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (aa144-173) (Biotin) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (aa144-173) (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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SFTPC / Surfactant Protein C Rabbit anti-Human Polyclonal (aa144-173) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).