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SETD1B / SET1B
SET Domain Containing 1B
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
| Gene Name: | SET Domain Containing 1B |
| Synonyms: | SETD1B, HSET1B, KIAA1076, Lysine N-methyltransferase 2G, KMT2G, SET domain containing 1B, Set1B |
| Target Sequences: | AB028999 BAA83028.1 Q9UPS6 |
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