Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC, IHC - Paraffin, Western blot, ELISA, Neutralization
Mouse Monoclonal (IgG1) to Human SERPINE1 / PAI-1
IHC, Western blot, ELISA
Human SERPINE1 / PAI-1
Human, Mouse (tested or 100% immunogen sequence identity)
Protein A purified
IHC - Paraffin
Specificity and Use
Recombinant Human PAI-1.
Recognizes PAI-1 and exhibits inhibitory characteristics. Binds to an epitope localized to the F-Helix of PAI-1. The PAI-1/mab complex acts as a substrate for its target proteinases tPA and uPA. Species cross-reactivity: Human and mouse.
Suitable for use in Western Blot, Immunohistochemistry and ELISA.
SERPINE1 / PAI-1 is a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.