Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 15H10] (IgG1) to Human SERPINA1 / Alpha 1 Antitrypsin
Human, Monkey, Dog
IHC - Paraffin, Western blot, Immunoprecipitation
Rabbit Polyclonal to Human SERPINA1 / Alpha 1 Antitrypsin
IHC - Paraffin
Human SERPINA1 / Alpha 1 Antitrypsin
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
Specificity and Use
Alpha-1-antitrypsin isolated from human serum.
The antibody is specific against human alpha-1-antitrypsin. stains macrophages in human tissues and does not stain any other cell type. This antibody shows cross reactivity against wide range of mammalian species.
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin.