Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 15H10] (IgG1) to Human SERPINA1 / Alpha 1 Antitrypsin
Human, Monkey, Dog
IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Mouse Monoclonal (IgG2a) to Human SERPINA1 / Alpha 1 Antitrypsin
IHC, IHC - Paraffin, ELISA
Human SERPINA1 / Alpha 1 Antitrypsin
Human (tested or 100% immunogen sequence identity)
Protein A purified
IHC - Paraffin (10 µg/ml)
Specificity and Use
Purified human serum alpha-1-antitrypsin.
Recognizes human alpha-1 antitrypsin, a serine protease inhibitor synthesized by the liver. Hereditary deficiency of this protein is associated with pulmonary emphysema and with liver disease, due to the loss of inhibition of neutrophil elastase activity. Shows minimal reactivity with other serum proteins including alpha-1-antichymotrypsin.
PBS, pH 7.2, 0.09% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin.