Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 133.1G6] (IgM) to Human SEMA4D / Semaphorin 4D / CD100
Immunoprecipitation, Flow Cytometry
Human SEMA4D / Semaphorin 4D / CD100
Human (tested or 100% immunogen sequence identity)
IgM Monoclonal [133.1G6]
Specificity and Use
SEMA4D / Semaphorin 4D / CD100 antibody was raised against pHA stimulated PBL. Splenocytes were fused with mouse myeloma NS1 cells.
133.1G6 reacts with human CD100, a novel 150 kD homodimer cell-surface antigen that is expressed on resting and PHA-stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor T cell lines. The mAb was clustered at the IV WLDA (workshop no. A022).
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro).