Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse (tested or 100% immunogen sequence identity)
IgG2a,k Monoclonal [MEL-14]
Specificity and Use
SELL / L-Selectin / CD62L antibody was raised against c3H/eb cloned mouse B lymphoma 38C-13.
Recognizes mouse CD62L/L-selectin, Mr 90kD. Blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.
Suitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry, in vivo and in vitro blocking of adhesion, and cytotoxicity studies. Flow Cytometry: 0.1 ug/1E6 cells.
PBS, 0.1% sodium azide, stabilizing agent.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
SELL / L-Selectin / CD62L is a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites.