Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human SELL / L-Selectin / CD62L
IHC, IHC - Paraffin, Western blot, Flow Cytometry
Mouse Monoclonal [clone DREG-56 (DREG56)] (IgG1,k) to Human SELL / L-Selectin / CD62L
PE, Cy5 Conjugated
Human SELL / L-Selectin / CD62L
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [DREG-56 (DREG56)]
Specificity and Use
The DREG-56 (DREG56) antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 20 ul (0.5 ug)/per test. A test is defined as the amount (ug)/test of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
SELL / L-Selectin / CD62L is a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites.
Staining of normal human peripheral blood cells with PE-Cy5 Mouse IgG1, K isotype control (open histogram) or PE-Cy5 anti-human CD62L (Dreg 56) (colored histogram). Cells in the lymphocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.