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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Securin / PTTG1 Antibody (N‑Terminus) LS‑C9840
PTTG1 antibody LS-C9840 is an unconjugated rabbit polyclonal antibody to human PTTG1 (Securin). Validated for ELISA, IHC and WB.
100 µg (0.25 mg/ml)

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Formalin-fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and AEC chromogen. Note nuclear staining of lymphocytes in germinal center.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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Product Description

PTTG1 antibody LS-C9840 is an unconjugated rabbit polyclonal antibody to human PTTG1 (Securin). Validated for ELISA, IHC and WB.
About Securin / PTTG1
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. O95997 NM_004219 NP_004210.1

PTTG1 Antibody, EAP1 Antibody, Esp1-associated protein Antibody, HPTTG Antibody, ESP1-associated protein 1 Antibody, Pituitary tumor-transforming 1 Antibody, TUTR1 Antibody, PTTG Antibody, Securin Antibody, Tumor-transforming protein 1 Antibody


Human Securin / PTTG1
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Immunoaffinity purified
  • IHC
  • IHC - Paraffin (1 - 2 µg/ml)
  • Western blot (2 - 4 µg/ml)
  • ELISA (0.1 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Securin / PTTG1 antibody was raised against synthetic peptide derived from the transactivation domain within the N-terminus of the human PTTG-1 protein.
Recognizes human PTTG-1. Expected to cross-react with mouse PTTG-1 based sequence homology. Reactivity confirmed with human MCF-7 cell lysate (Western Blot) and colon cancer tissue (IHC, paraffin).
Suitable for use in ELISA, Western Blot and Immunohistochemistry. ELISA: 0.1-1 ug/ml. Western Blot: 2-4 ug/ml. Recognizes only the 28kD band in MCF-7 cell lysate. Immunohistochemistry: 1-2 ug/ml in formalin-fixed, paraffin embedded tissues. For best results heat induced epitope retrieval (HIER) with citrate buffer, pH 6.0, is required prior to staining.
PBS, pH 7.4, 0.1% Sodium Azide
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
For research use only.

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Requested From: United States
Date Requested: 9/24/2018

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