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Anti-Securin / PTTG1 Antibody (N-Terminus) LS-C9840

Catalog Size Price
LS-C9840-100 100 µg (0.25 mg/ml) Unavailable

Most Popular Securin / PTTG1 Antibodies

Anti-Securin / PTTG1 Antibody (N-Terminus) LS-C9840
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
IHC, IHC - Paraffin, Western blot, ELISA
Anti-Securin / PTTG1 Antibody (clone DCS-280, Azide-free) LS-C87800
Mouse Monoclonal [clone DCS-280] (IgG2a,k) to Human Securin / PTTG1
IHC, IHC - Paraffin
Unconjugated, Azide-free
Formalin-fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and AEC chromogen. Note nuclear staining of lymphocytes in germinal center.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Anti-Securin / PTTG1 Antibody (aa148-160) IHC-plus™ LS-B5119
Goat Polyclonal to Human Securin / PTTG1
Human, Monkey, Mouse
IHC, IHC - Paraffin
Anti-PTTG1 / Securin antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5119 concentration 2.5 ug/ml.
Anti-Securin / PTTG1 Antibody (Internal) LS-C153548
Rabbit Polyclonal to Human Securin / PTTG1
Human, Mouse
IHC, Western blot, ELISA
Anti-Securin / PTTG1 Antibody (aa2-199, Biotin) LS-C687420
Rabbit Polyclonal (IgG) to Mouse Securin / PTTG1
Mouse, Human
IHC, Western blot
Biotin Conjugated

100% Guaranteed
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
IHC, IHC - Paraffin, Western blot, ELISA (applications tested for the base form of this product only)


Human Securin / PTTG1
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Immunoaffinity purified


  • IHC
  • IHC - Paraffin (1 - 2 µg/ml)
  • Western blot (2 - 4 µg/ml)
  • ELISA (0.1 - 1 µg/ml)
  • (applications tested for the base form of this product only)

Specificity and Use

Securin / PTTG1 antibody was raised against synthetic peptide derived from the transactivation domain within the N-terminus of the human PTTG-1 protein.
Recognizes human PTTG-1. Expected to cross-react with mouse PTTG-1 based sequence homology. Reactivity confirmed with human MCF-7 cell lysate (Western Blot) and colon cancer tissue (IHC, paraffin).
Suitable for use in ELISA, Western Blot and Immunohistochemistry. ELISA: 0.1-1 ug/ml. Western Blot: 2-4 ug/ml. Recognizes only the 28kD band in MCF-7 cell lysate. Immunohistochemistry: 1-2 ug/ml in formalin-fixed, paraffin embedded tissues. For best results heat induced epitope retrieval (HIER) with citrate buffer, pH 6.0, is required prior to staining.


PBS, pH 7.4, 0.1% sodium azide.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About Securin / PTTG1

O95997 NM_004219 NP_004210.1

PTTG1 Antibody, EAP1 Antibody, Esp1-associated protein Antibody, HPTTG Antibody, ESP1-associated protein 1 Antibody, Pituitary tumor-transforming 1 Antibody, TUTR1 Antibody, PTTG Antibody, Securin Antibody, Tumor-transforming protein 1 Antibody

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.

Requested From: 
Date Requested: 5/20/2018

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