LSBio
Products
  • Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA and Assay Kits
  • All Kits
  • Assay Kits
  • Traditional ELISA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Phospho-Specific ELISA Kits
  • ELISA Development Kits
  • Chemiluminescent CLIA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Biochemicals
  • All Biochemicals

  • Immunohistochemistry
  • Immunohistochemistry Reagents
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
Services
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question? CustomerSupport@LSBio.com
Resources
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Reviews
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Protocols
  • Secure Logins
  • Login to Our Secure ShareFile Site
  • Login to Our IHC Database
Distributors
Contact Us

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login ▾
Wish List
View Cart

Anti-Securin / PTTG1 Antibody (N-Terminus) LS-C9840

Catalog Size Price
LS-C9840-100 100 µg (0.25 mg/ml) Unavailable

Most Popular Securin / PTTG1 Antibodies

Anti-Securin / PTTG1 Antibody (N-Terminus) LS-C9840
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Anti-Securin / PTTG1 Antibody (clone DCS-280, Azide-free) LS-C87800
Mouse Monoclonal [clone DCS-280] (IgG2a,k) to Human Securin / PTTG1
Human
IHC - Paraffin
Unconjugated, Azide-free
Formalin-fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and AEC chromogen. Note nuclear staining of lymphocytes in germinal center.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Anti-Securin / PTTG1 Antibody (aa148-160) IHC-plus™ LS-B5119
Goat Polyclonal to Human Securin / PTTG1
Human, Monkey, Mouse
IHC - Paraffin
Unconjugated
Anti-PTTG1 / Securin antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5119 concentration 2.5 ug/ml.
Anti-Securin / PTTG1 Antibody (Internal) LS-C153548
Rabbit Polyclonal to Human Securin / PTTG1
Human, Mouse
IHC, Western blot, ELISA
Unconjugated
Anti-Securin / PTTG1 Antibody IHC-plus™ LS-B14918
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
Human, Mouse, Rat
IHC, IHC - Paraffin, Western blot
Unconjugated
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

100% Guaranteed
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
Human
IHC - Paraffin, Western blot, ELISA (applications tested for the base form of this product only)
Unconjugated

Details

Human Securin / PTTG1
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (1 - 2 µg/ml)
  • Western blot (2 - 4 µg/ml)
  • ELISA (0.1 - 1 µg/ml)
  • (applications tested for the base form of this product only)

Specificity and Use

Securin / PTTG1 antibody was raised against synthetic peptide derived from the transactivation domain within the N-terminus of the human PTTG-1 protein.
N-Terminus
Recognizes human PTTG-1. Expected to cross-react with mouse PTTG-1 based sequence homology. Reactivity confirmed with human MCF-7 cell lysate (Western Blot) and colon cancer tissue (IHC, paraffin).
Suitable for use in ELISA, Western Blot and Immunohistochemistry. ELISA: 0.1-1 ug/ml. Western Blot: 2-4 ug/ml. Recognizes only the 28kD band in MCF-7 cell lysate. Immunohistochemistry: 1-2 ug/ml in formalin-fixed, paraffin embedded tissues. For best results heat induced epitope retrieval (HIER) with citrate buffer, pH 6.0, is required prior to staining.

Packaging

PBS, pH 7.4, 0.1% sodium azide.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About Securin / PTTG1

O95997 NM_004219 NP_004210.1

PTTG1 Antibody, EAP1 Antibody, Esp1-associated protein Antibody, HPTTG Antibody, ESP1-associated protein 1 Antibody, Pituitary tumor-transforming 1 Antibody, TUTR1 Antibody, PTTG Antibody, Securin Antibody, Tumor-transforming protein 1 Antibody

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.

Requested From: 
Date Requested: 4/20/2018

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy



Catalog Number