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Anti-Securin / PTTG1 Antibody (Internal) LS-C145186

Ordering

Wt. Vol. Conc. Price
- 100 µl - $365
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular Securin / PTTG1 Antibodies

Anti-Securin / PTTG1 Antibody (clone DCS-280, Azide-free) LS-C87800
Mouse Monoclonal [clone DCS-280] (IgG2a,k) to Human Securin / PTTG1
Human
IHC - Paraffin
Unconjugated, Azide-free
Immunohistochemistry Image
Anti-Securin / PTTG1 Antibody (aa148-160) IHC-plus™ LS-B5119
Goat Polyclonal to Human Securin / PTTG1
Human, Monkey, Mouse
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-Securin / PTTG1 Antibody (Internal) LS-C153548
Rabbit Polyclonal to Human Securin / PTTG1
Human, Mouse
IHC, Western blot, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human Securin / PTTG1
Human
IHC, Western blot, ELISA
Unconjugated

Details

Human Securin / PTTG1
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Antiserum
Unmodified

Applications

  • IHC (1:50 - 1:200)
  • Western blot (1:200 - 1:1000)
  • ELISA

Specificity and Use

Securin / PTTG1 antibody was raised against synthetic peptide derived from internal domain of the human Securin protein
Internal
Human 22 kD protein

Packaging

Lyophilized antiserum
100 µl Distilled water
Store lyophilized at -20°C for 2 years. Stable at 4°C for at least one month or for six months in aliquots at -20°C. Avoid freeze/thaw cycles.
For research use only.

About Securin / PTTG1

O95997 NM_004219 NP_004210.1

PTTG1 Antibody, EAP1 Antibody, Esp1-associated protein Antibody, HPTTG Antibody, ESP1-associated protein 1 Antibody, Pituitary tumor-transforming 1 Antibody, TUTR1 Antibody, PTTG Antibody, Securin Antibody, Tumor-transforming protein 1 Antibody

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.

Requested From: United States
Date Requested: 12/9/2016

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