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Anti-Securin / PTTG1 Antibody LS-C74223

Catalog Size Price
LS-C74223-500 500 µl Unavailable

Most Popular Securin / PTTG1 Antibodies

Anti-Securin / PTTG1 Antibody (N-Terminus) LS-C9840
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Anti-Securin / PTTG1 Antibody (clone DCS-280, Azide-free) LS-C87800
Mouse Monoclonal [clone DCS-280] (IgG2a,k) to Human Securin / PTTG1
Human
IHC - Paraffin
Unconjugated, Azide-free
Immunohistochemistry Image
Anti-Securin / PTTG1 Antibody (aa148-160) IHC-plus™ LS-B5119
Goat Polyclonal to Human Securin / PTTG1
Human, Monkey, Mouse
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-Securin / PTTG1 Antibody (Internal) LS-C153548
Rabbit Polyclonal to Human Securin / PTTG1
Human, Mouse
IHC, Western blot, ELISA
Unconjugated
Anti-Securin / PTTG1 Antibody IHC-plus™ LS-B14918
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
Human, Mouse, Rat
IHC, IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry - Paraffin Image

100% Guaranteed
Mouse Monoclonal (IgG2a) to Human Securin / PTTG1
Human
IHC - Paraffin
Unconjugated

Details

Human Securin / PTTG1
Mouse
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal
Unconjugated
Protein A purified
Unmodified

Applications

IHC - Paraffin

Specificity and Use

Securin / PTTG1 antibody was raised against human recombinant full length Pds1 protein.
Recognizes Pds1. Species cross-reactivity: human.
Western Blot (Not verified), Immunohistochemistry (formalin/paraffin) (Ab 1-2 ug/ml for 30 min at RT). Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Positive control: HeLa cells. Tonsil.

Packaging

10 mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
For research use only.

About Securin / PTTG1

O95997 NM_004219 NP_004210.1

PTTG1 Antibody, EAP1 Antibody, Esp1-associated protein Antibody, HPTTG Antibody, ESP1-associated protein 1 Antibody, Pituitary tumor-transforming 1 Antibody, TUTR1 Antibody, PTTG Antibody, Securin Antibody, Tumor-transforming protein 1 Antibody

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.

Requested From: 
Date Requested: 12/17/2017

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