Securin / PTTG1

pituitary tumor-transforming 1

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

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Products

Antibodies (50)

Proteins (8)

ELISA Kits (1)

Type

Cell-Based (1)

Over-Expression Lysate (2)

Primary (50)

Recombinant (6)

Target

Securin / PTTG1 (59)

Reactivity

Human (51)

Mouse (13)

Rat (2)

Monkey (2)

Application

IHC (22)

IHC-P (8)

WB (37)

ELISA (12)

ICC (2)

IF (8)

IP (1)

Peptide-ELISA (3)

Host

rabbit (41)

mouse (8)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (17)

IgG2a (7)

IgG2b,k (1)

Clonality

monoclonal mc (8)

polyclonal pc (42)

Clone

2C3 (1)

Format

96-Well Microplate (1)

APC (2)

APC Conjugated (4)

Azide-free (1)

Biotin Conjugated (5)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (4)

Unconjugated (23)

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Epitope

aa2-199 (8)

aa2-202 (8)

Internal (3)

Leu149 (1)

N-Terminus (1)

aa111-160 (1)

aa146-161 (1)

aa148-160 (1)

aa16-45 (1)

Publications

No (58)

Yes (1)

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Adherent Cell Cultures (1)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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IHC-plus™ Securin / PTTG1 Antibody (aa148-160) LS-B5119

(5.0) Rating

(1) Publication(s)

Antibody:

Securin / PTTG1 Goat anti-Human Polyclonal (aa148-160) Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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Securin / PTTG1 Antibody (Internal) LS-C153548

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$440; 100 µg/$480

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Securin / PTTG1 Antibody (N-Terminus) LS-C9840

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$748

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Securin / PTTG1 Antibody (HRP) LS-C549105

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$989

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Securin / PTTG1 Antibody (Biotin) LS-C529011

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$989

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Securin / PTTG1 Antibody (FITC) LS-C538956

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$989

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Securin / PTTG1 Antibody (APC) LS-C518985

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

100 µl/$989

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Securin / PTTG1 Antibody (PE) LS-C657106

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

100 µl/$989

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE

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IHC-plus™ Securin / PTTG1 Antibody LS-B14918

(4.0) Rating

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Securin / PTTG1 Antibody (Internal) LS-C353139

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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Securin / PTTG1 Antibody (aa2-199) LS-C374646

Antibody:

Securin / PTTG1 Rabbit anti-Mouse Polyclonal (aa2-199) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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Securin / PTTG1 Antibody (aa2-199, Biotin) LS-C687420

Antibody:

Securin / PTTG1 Rabbit anti-Mouse Polyclonal (aa2-199) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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Securin / PTTG1 Antibody (aa16-45) LS-C100534

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (aa16-45) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Securin / PTTG1 Antibody (Leu149) LS-C176719

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (Leu149) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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Human Securin / PTTG1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70054

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.8 kDa

Price:

20 µg/$1,107

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Securin / PTTG1 Antibody LS-C800470

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Securin / PTTG1 Antibody LS-C416045

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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Securin / PTTG1 Antibody (Internal) LS-C145186

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

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Securin / PTTG1 Antibody LS-C822536

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

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Securin / PTTG1 Antibody (aa111-160) LS-C118744

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal (aa111-160) Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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Securin / PTTG1 Antibody LS-C74223

Antibody:

Securin / PTTG1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

500 µl/$876

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Securin / PTTG1 Antibody (Azide-free) LS-C74225

Antibody:

Securin / PTTG1 Mouse anti-Human Monoclonal (Azide-free) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated, Azide-free

Price:

100 µl/$916

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Securin / PTTG1 Antibody LS-C769984

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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Securin / PTTG1 Antibody LS-C402526

Antibody:

Securin / PTTG1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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Securin / PTTG1 Antibody (clone 2C3) LS-C139438

Antibody:

Securin / PTTG1 Mouse anti-Human Monoclonal (2C3) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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