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Anti-Securin / PTTG1 Antibody (aa111-160) LS-C118744

Ordering

Wt. Vol. Conc. Price
- 20 µl - $205
- 50 µl - $255
- 100 µl - $315
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular Securin / PTTG1 Antibodies

Anti-Securin / PTTG1 Antibody (clone DCS-280, Azide-free) LS-C87800
Mouse Monoclonal [clone DCS-280] (IgG2a,k) to Human Securin / PTTG1
Human
IHC - Paraffin
Unconjugated, Azide-free
Immunohistochemistry Image
Anti-Securin / PTTG1 Antibody (aa148-160) IHC-plus™ LS-B5119
Goat Polyclonal to Human Securin / PTTG1
Human, Monkey, Mouse
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-Securin / PTTG1 Antibody (Internal) LS-C153548
Rabbit Polyclonal to Human Securin / PTTG1
Human, Mouse
IHC, Western blot, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
Human
Immunofluorescence, Western blot, ELISA
Unconjugated

Details

Human Securin / PTTG1
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • Immunofluorescence
  • Western blot
  • ELISA

Specificity and Use

Securin / PTTG1 antibody was raised against synthetic peptide from human PTTG1 (aa111-160).
aa111-160
PTTG1 Antibody detects endogenous levels of total PTTG1 protein.

Packaging

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Store at -20°C for up to one year.
For research use only.

About Securin / PTTG1

O95997 NM_004219 NP_004210.1

PTTG1 Antibody, EAP1 Antibody, Esp1-associated protein Antibody, HPTTG Antibody, ESP1-associated protein 1 Antibody, Pituitary tumor-transforming 1 Antibody, TUTR1 Antibody, PTTG Antibody, Securin Antibody, Tumor-transforming protein 1 Antibody

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.

Immunofluorescence

Immunofluorescence
Immunofluorescence of HUVEC cells, using PTTG1 Antibody. The picture on the right is treated with the synthesized peptide.

Western blot

Western blot
Western blot of extracts from HepG2/Jurkat/293 cells, using PTTG1 Antibody. The lane on the right is treated with the synthesized peptide.

Requested From: United States
Date Requested: 12/2/2016

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