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SDS encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver.
Gene Name: | serine dehydratase |
Synonyms: | SDS, L-serine ammonia-lyase, L-serine dehydratase, Serine dehydratase, SDH, TDH, L-serine deaminase, L-threonine dehydratase |
Target Sequences: | NM_006843 NP_006834.2 P20132 |
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