Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
Specificity and Use
SDF1 / CXCL12 antibody was raised against e. coli-expressed human SDF-1 alpha.
The antibody can be used for Western blot analysis (0.5-1 ug/ml). Based on researcher's feedback, it can also be used in ELISA (2-3 ug/ml), and neutralization (2-10 ug/ml). However, the optimal conditions should be determined individually
PBS, pH 7.2, 30% glycerol, 0.01 Thimerosal.
+4°C or -20°C, Avoid repeated freezing and thawing.
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity.