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SCN5A / Nav1.5 Antibody (aa1021‑1034) LS‑C154846
Antibody
Nav1.5 antibody LS-C154846 is an unconjugated goat polyclonal antibody to Nav1.5 (SCN5A) from human and monkey. Validated for Peptide-ELISA.
Catalog
Size
Price
LS-C154846-100
100 µg (0.5 mg/ml)
Unavailable

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Product Description

Nav1.5 antibody LS-C154846 is an unconjugated goat polyclonal antibody to Nav1.5 (SCN5A) from human and monkey. Validated for Peptide-ELISA.
About SCN5A / Nav1.5
Scn5a encodes the alpha subunit of the type V voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type V channel has been shown to be tetrodotoxin-resistant. Q14524 NM_000335 NP_000326.2

SCN5A Antibody, CDCD2 Antibody, CMPD2 Antibody, HB1 Antibody, HB2 Antibody, HH1 Antibody, HBBD Antibody, Nav1.5 Antibody, IVF Antibody, RSKM2X Antibody, SCAL Antibody, Scn2x Antibody, LQT3 Antibody, SSS1 Antibody, MH1 Antibody, VF1 Antibody, PFHB1 Antibody, RATRSKM2X Antibody, SkM2 Antibody, CMD1E Antibody, ICCD Antibody, RH1 Antibody, RSkM2 Antibody


Specifications

Target
Human SCN5A / Nav1.5
Host
Goat
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Peptide Enzyme-Linked Immunosorbent Assay (1:16000)
Immunogen
SCN5A / Nav1.5 antibody was raised against synthetic peptide C-PTRKETRFEEGEQP from an internal region of human SCN5A / Nav1.5 (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey (100%); Marmoset (86%).
Blocking Peptide
LS-E27655 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C154846. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa1021-1034
Specificity
Human SCN5A / Nav1.5. This antibody is expected to recognize all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1).
Usage
Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Preliminary experiments gave an approx 80kD band in HeLa lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 227kD according to NP_932173.1. The 80kD band was successfully blocked by incubation with the immunizing peptide.
Presentation
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/21/2018

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