SATB1

SATB homeobox 1

Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

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Antibodies (42)

Proteins (7)

ELISA Kits (1)

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Over-Expression Lysate (4)

Primary (42)

Recombinant (3)

Sandwich (1)

Target

SATB1 (50)

Reactivity

Human (41)

Mouse (15)

Rat (13)

Chimpanzee (9)

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rabbit (24)

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monoclonal mc (17)

polyclonal pc (25)

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3548D4_2a (2)

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IHC-plus™ SATB1 Antibody LS-B2690

(4.0) Rating

Antibody:

SATB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ SATB1 Antibody (aa668-681) LS-B8311

(4.0) Rating

Antibody:

SATB1 Goat anti-Human Polyclonal (aa668-681) Antibody

Reactivity:

Rabbit, Mouse, Rat, Hamster, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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SATB1 Antibody LS-C53327

Antibody:

SATB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$335

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SATB1 Antibody LS-C482503

Antibody:

SATB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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SATB1 Antibody (clone OTI4E1) LS-C114621

Antibody:

SATB1 Mouse anti-Human Monoclonal (OTI4E1) Antibody

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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SATB1 Antibody (clone OTI4E1, Carrier-free) LS-C784345

Antibody:

SATB1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4E1) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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SATB1 Antibody (clone OTI11E8) LS-C114686

Antibody:

SATB1 Mouse anti-Human Monoclonal (OTI11E8) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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SATB1 Antibody (clone OTI11E8, Carrier-free) LS-C784388

Antibody:

SATB1 Mouse anti-Human Monoclonal (Carrier-free) (OTI11E8) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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SATB1 Antibody (clone OTI11H4) LS-C114620

Antibody:

SATB1 Mouse anti-Human Monoclonal (OTI11H4) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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SATB1 Antibody (clone OTI11H4, Carrier-free) LS-C784344

Antibody:

SATB1 Mouse anti-Human Monoclonal (Carrier-free) (OTI11H4) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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SATB1 Antibody (clone OTI13D6) LS-C114619

Antibody:

SATB1 Mouse anti-Human Monoclonal (OTI13D6) Antibody

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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SATB1 Antibody (clone OTI13D6, Carrier-free) LS-C784343

Antibody:

SATB1 Mouse anti-Human Monoclonal (Carrier-free) (OTI13D6) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SATB1 Antibody (clone OTI3E12) LS-C114675

Antibody:

SATB1 Mouse anti-Human Monoclonal (OTI3E12) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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SATB1 Antibody (clone OTI3E12, Carrier-free) LS-C799268

Antibody:

SATB1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3E12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SATB1 Antibody (clone OTI10G2) LS-C114649

Antibody:

SATB1 Mouse anti-Human Monoclonal (OTI10G2) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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SATB1 Antibody (clone OTI10G2, Carrier-free) LS-C797088

Antibody:

SATB1 Mouse anti-Human Monoclonal (Carrier-free) (OTI10G2) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SATB1 Antibody LS-C662521

Antibody:

SATB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IHC, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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SATB1 Antibody (clone 3548D4_2a) LS-C342734

Antibody:

SATB1 Mouse anti-Human Monoclonal (3548D4_2a) Antibody

Reactivity:

Human

Applications:

DB, ICC, IF, WB

Format:

Unconjugated

Price:

100 µg/$486

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SATB1 Antibody LS-C334301

Antibody:

SATB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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SATB1 Antibody (clone OTI6C6) LS-C114644

Antibody:

SATB1 Mouse anti-Human Monoclonal (OTI6C6) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SATB1 Antibody (clone OTI6C6, Carrier-free) LS-C784359

Antibody:

SATB1 Mouse anti-Human Monoclonal (Carrier-free) (OTI6C6) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SATB1 Antibody (clone 3548D4_2a) LS-C184703

Antibody:

SATB1 Mouse anti-Human Monoclonal (3548D4_2a) Antibody

Reactivity:

Human

Applications:

DB, ICC, WB

Format:

Unconjugated

Price:

100 µg/$965

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SATB1 Antibody (C-Terminus) LS-C126247

Antibody:

SATB1 Mouse anti-Human Monoclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$786

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SATB1 Antibody LS-C341875

Antibody:

SATB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

SATB1 Antibody LS-C752457

Antibody:

SATB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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