Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Mouse, Rat, Bovine (at least 90% immunogen sequence identity)
Western blot (1:1000 - 1:10000)
Specificity and Use
SART1 antibody was raised against recombinant fragment corresponding to a region within amino acids 533 and 792 of SART1 (SwissProt O43290). Percent identity by BLAST analysis: Human (100%); Mouse, Rat, Bovine (99%); Xenopus (89%); Zebrafish (81%).
0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
SART1 Antibody, Ara1 Antibody, Allergen Hom s 1 Antibody, HOMS1 Antibody, HSnu66 Antibody, IgE autoantigen Antibody, SART-1 Antibody, Snu66 Antibody, SNRNP110 Antibody, SNU66 homolog Antibody, SART1(800) protein Antibody, SART1259 Antibody, HSART-1 Antibody, SART1(259) protein Antibody
SART1 is two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens.