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SARM1 / SARM
sterile alpha and TIR motif containing 1
Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.
| Gene Name: | sterile alpha and TIR motif containing 1 |
| Synonyms: | SARM1, Tir-1 homolog, SARM, KIAA0524, SAMD2 |
| Target Sequences: | NM_015077 NP_055892.2 Q6SZW1 |
Publications (1)
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