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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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S1PR1 / EDG1 / S1P1 Antibody (aa350‑400) LS‑C148693
S1P1 antibody LS-C148693 is an unconjugated rabbit polyclonal antibody to S1P1 (S1PR1 / EDG1) from human and rat. Validated for WB.
Catalog
Size
Price
LS-C148693-100
100 µg
Unavailable

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Product Description

S1P1 antibody LS-C148693 is an unconjugated rabbit polyclonal antibody to S1P1 (S1PR1 / EDG1) from human and rat. Validated for WB.
About S1PR1 / EDG1 / S1P1
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. P21453 NM_001400 NP_001391.2

S1PR1 Antibody, CD363 Antibody, CD363 antigen Antibody, CHEDG1 Antibody, ECGF1 Antibody, EDG-1 Antibody, D1S3362 Antibody, EDG1 Antibody, S1P1 Antibody, S1P receptor Edg-1 Antibody, S1P receptor 1 Antibody


Specifications

Target
Human S1PR1 / EDG1 / S1P1
Host
Rabbit
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Western blot (4 - 6 µg/ml)
Immunogen
A portion of amino acids 350-400 of human S1PR1.
Epitope
aa350-400
Specificity
Human S1PR1 / EDG1.
Presentation
PBS, 0.05% BSA, 0.05% sodium azide
Storage
Store at 4°C, stable for 6 months. For long term storage, aliquot and store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Western blot

Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Western blot

Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Western blot

Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.


Requested From: 
Date Requested: 6/17/2018

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