S100A12

S100 calcium binding protein A12

S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

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Antibodies (52)

ELISA Kits (21)

Proteins (14)

Type

Custom (1)

Development Kit (2)

Over-Expression Lysate (2)

Primary (52)

Recombinant (12)

Sandwich (17)

Sandwich CLIA (1)

Target

S100A12 (87)

Reactivity

Human (56)

Bovine (8)

Chicken (1)

Cow (8)

Guinea pig (1)

Monkey (1)

Pig (17)

Porcine (1)

Rabbit (3)

Application

IHC (12)

IHC-P (5)

WB (43)

ELISA (9)

IF (1)

Peptide-ELISA (1)

Host

rabbit (40)

mouse (12)

Product Group

DevKit DuoPlus (2)

IHCPlus (3)

Isotype

IgG (8)

IgG1 (2)

IgG1,k (1)

IgG2a,k (1)

IgG2b,k (8)

Clonality

monoclonal mc (12)

polyclonal pc (40)

Clone

19F5 (1)

1D1 (2)

1F10 (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (3)

96-Well Strip Plate (15)

Antibody Pair and Standard (2)

APC (4)

APC Conjugated (4)

Biotin Conjugated (4)

Carrier-free (1)

Cy3 Conjugated (4)

Cy7 Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (4)

Unconjugated (24)

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Epitope

aa2-92 (16)

aa1-92 (9)

Publications

No (87)

Sample Type

Cell Culture Supernatants (7)

Cell Lysates (5)

Plasma (16)

Serum (16)

Tissue Homogenates (5)

Tag

GST (2)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-S (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Bovine (1)

Human (10)

Pig (1)

Rabbit (1)

Source

293T Cells (1)

E. coli (9)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

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S100A12 Antibody (clone 19F5) LS-C153339

Antibody:

S100A12 Mouse anti-Human Monoclonal (19F5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$440; 100 µg/$468

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Human S100A12 (Sandwich ELISA) ELISA Kit - LS-F12541

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Pig S100A12 (Sandwich ELISA) ELISA Kit - LS-F17699

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human S100A12 (Sandwich ELISA) ELISA Kit - LS-F4417

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$685

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IHC-plus™ S100A12 Antibody (clone 1D1) LS-B12392

(4.0) Rating

Antibody:

S100A12 Mouse anti-Human Monoclonal (1D1) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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S100A12 Antibody (clone 1D1, Carrier-free) LS-C785701

Antibody:

S100A12 Mouse anti-Human Monoclonal (Carrier-free) (1D1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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S100A12 Antibody (aa1-92) LS-C296306

Antibody:

S100A12 Rabbit anti-Human Polyclonal (aa1-92) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$483; 1 ml/$551; 2 ml/$734; 5 ml/$1,201

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S100A12 Antibody (aa1-92, Biotin) LS-C299098

Antibody:

S100A12 Rabbit anti-Human Polyclonal (aa1-92) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$315; 200 µl/$360; 500 µl/$510; 1 ml/$585; 2 ml/$805; 5 ml/$1,309

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

IHC-plus™ S100A12 Antibody LS-B15412

(4.0) Rating

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

Human S100A12 (Sandwich ELISA) ELISA Kit - LS-F22946

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human S100A12 (Sandwich ELISA) ELISA Kit - LS-F21068

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Porcine S100A12 (Sandwich ELISA) ELISA Kit - LS-F38564

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human S100A12 Protein (Recombinant) (Met1-Glu92) - LS-G39144

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

10.6kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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IHC-plus™ S100A12 Antibody LS-B15402

(4.0) Rating

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

60 µl/$460

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S100A12 Antibody LS-C660587

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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S100A12 Antibody LS-C489033

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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S100A12 Antibody LS-C806597

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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S100A12 Antibody LS-C341576

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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S100A12 Antibody (clone 1F10) LS-C139078

Antibody:

S100A12 Mouse anti-Human Monoclonal (1F10) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$423

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S100A12 Antibody LS-C489030

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

Select

S100A12 Antibody LS-C780529

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

S100A12 Antibody LS-C747596

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

S100A12 Antibody LS-C770420

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

S100A12 Antibody LS-C831576

Antibody:

S100A12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439

Select

S100A12 Antibody LS-C663650

Antibody:

S100A12 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$295; 200 µl/$331; 500 µl/$451; 1 ml/$511; 2 ml/$648; 5 ml/$1,099

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