Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Western blot (1:1000)
Specificity and Use
RYR1 / RYR antibody was raised against synthetic peptide from the variant TM region of human Ryanodine Receptor 1
Ryanodine Receptor 1
Western blot: 1:1000 using ECL. The antibody reacts with the 500 kD Ryanodine Receptor 1 protein. Suggested blocking buffer is 10% normal goat serum (or same host as your secondary antibody), 1% BSA in 0.1 M PBS with 0.05% Tween 20. Suggested dilution buf
Store at -20°C. Aliquot to avoid freeze-thaw cycles. Store undiluted.
RYR1 Antibody, CCO Antibody, Central core disease of muscle Antibody, MHS Antibody, RYDR Antibody, Ryanodine receptor type 1 Antibody, RYR-1 Antibody, SKRR Antibody, Type 1 ryanodine receptor Antibody, Ryanodine receptor 1 Antibody, Ryanodine receptor type1 Antibody, MHS1 Antibody, RyR Antibody, Type 1-like ryanodine receptor Antibody
Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain.