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RYK

receptor-like tyrosine kinase

RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: receptor-like tyrosine kinase
Family/Subfamily: Protein Kinase , RYK
Synonyms: RYK, D3S3195, Hydroxyaryl-protein kinase, JTK5, JTK5A protein tyrosine kinase, RYK1, Vik, Tyrosine-protein kinase RYK, Receptor-like tyrosine kinase, JTK5A, Tyrosine kinase ryk
Target Sequences: NM_002958 NP_002949.2 P34925

Publications (1)

1
The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. Keeble TR, Halford MM, Seaman C, Kee N, Macheda M, Anderson RB, Stacker SA, Cooper HM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:5840-8. [PubMed:16723543] Related Antibodies: LS-C99132.

☰ Filters
Antibodies (68)
Proteins (11)
Over-Expression Lysate (5)
Primary (68)
Recombinant (6)
RYK (79)
Human (66)
Mouse (38)
Rat (20)
Bat (1)
Bovine (1)
Dog (1)
Horse (1)
Monkey (1)
Xenopus (1)
IHC (26)
IHC-P (4)
WB (63)
Flo (1)
ELISA (33)
IF (1)
Peptide-ELISA (3)
rabbit (57)
mouse (9)
goat (1)
sheep (1)
IgG (26)
IgG1 (1)
IgG1,k (1)
IgG2b,k (7)
monoclonal mc (9)
polyclonal pc (59)
1671CT575.42.61 (1)
240CT2.2.4 (7)
AP Conjugated (1)
APC (2)
APC Conjugated (7)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 594 Conjugated (1)
Azide-free (4)
Biotin Conjugated (8)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (8)
HRP Conjugated (7)
PE Conjugated (6)
PerCP Conjugated (1)
Preservative Free (1)
RPE Conjugated (1)
Unconjugated (22)
aa287-533 (8)
aa308-570 (8)
aa160-190 (7)
aa196-413 (7)
aa321-348 (7)
aa561-591 (7)
aa383-410 (1)
aa98-110 (1)
No (78)
Yes (1)
DDK (Flag)-His, C-terminus (1)
GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (7)
Human (9)
Mouse (1)
293T Cells (3)
E. coli (2)
HEK 293 Cells (5)
Wheat Germ Extract (1)
RYK Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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RYK Rabbit anti-Human Polyclonal (aa160-190) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400 µl/$393
RYK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67.6 kDa
100 µg/$710
RYK Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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RYK Rabbit anti-Human Polyclonal (aa561-591) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
RYK Antibody - Western blot of recombinant RYK.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RYK Rabbit anti-Mouse Polyclonal (aa287-533) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
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RYK Sheep anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$930
Select
RYK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
RYK Antibody - Immunohistochemistry Dilution at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
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RYK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
RYK Protein - Recombinant  Related To Receptor Tyrosine Kinase By SDS-PAGE
Select
E. coli
His-T7
33.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
RYK Antibody - Anti-RYK Antibody at 1:1000 dilution + human lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 68 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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RYK Mouse anti-Human Monoclonal (1671CT575.42.61) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$393
Select
RYK Rabbit anti-Human Polyclonal (aa160-190) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
RYK Rabbit anti-Human Polyclonal (aa160-190) (Biotin) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa160-190) (FITC) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa160-190) (APC) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa160-190) (PE) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa160-190) (Azide-free) (HRP) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa561-591) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
RYK Rabbit anti-Human Polyclonal (aa561-591) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa561-591) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa561-591) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa561-591) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
RYK Rabbit anti-Human Polyclonal (aa561-591) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
RYK Rabbit anti-Mouse Polyclonal (aa321-348) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
Select
RYK Mouse anti-Human Monoclonal (aa196-413) (240CT2.2.4) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
RYK Antibody - Immunohistochemistry analysis using Rabbit Anti-RYK Polyclonal Antibody. Tissue: Breast Cancer. Species: Human. Fixation: Formalin Fixed Paraffin-Embedded. Primary Antibody: Rabbit Anti-RYK Polyclonal Antibody  at 1:50 for 30 min at RT. Counterstain: Hematoxylin. Magnification: 10X. HRP-DAB Detection.
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RYK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µg/$442
Select
RYK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$394
Viewing 1-25 of 79 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).