Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
RUNX1T1 Antibody, AML1T1 Antibody, CBFA2T1 Antibody, CDR Antibody, Eight twenty one protein Antibody, Cyclin-D-related protein Antibody, ETO Antibody, MTG8 Antibody, Protein CBFA2T1 Antibody, Protein ETO Antibody, ZMYND2 Antibody, Protein MTG8 Antibody
RUNX1T1 / ETO is a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene.
Immunofluorescence of monoclonal antibody to RUNX1T1 on HeLa cell . [antibody concentration 10 ug/ml]
Western Blot analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 monoclonal antibody (M01), clone 5A12.Lane 1: RUNX1T1 transfected lysate(67.566 KDa).Lane 2: Non-transfected lysate.
Enzyme-Linked Immunosorbent Assay
Detection limit for recombinant GST tagged RUNX1T1 is approximately 0.3 ng/ml as a capture antibody.