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RTN4 / Nogo
reticulon 4
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
| Gene Name: | reticulon 4 |
| Family/Subfamily: | Reticulon |
| Synonyms: | RTN4, Human NogoA, My043 protein, Neurite outgrowth inhibitor, NOGOC, NSP-CL, Nogo protein, KIAA0886, Reticulon 5, Reticulon-4, Reticulon-5, Reticulon 4, RTN4-B1, RTN-X, RTN4-A, RTN4-B2, RTN4-C, Nbla00271, Neurite growth inhibitor 220, NI220/250, NOGO-A, Nogo-C, ASY, Foocen, Nbla10545, NOGO, Nogo-B, NSP |
| Target Sequences: | NM_020532 NP_065393.1 Q9NQC3 |
Publications (1)
1
Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Sissy Kalayil, Sagar Bhogaraju, Florian Bonn, Donghyuk Shin, Yaobin Liu, Ninghai Gan, Jérôme Basquin, Paolo Grumati, Zhao-Qing Luo, Ivan Dikic. Nature. 2018 May;557:734-738. [Full Text Article]
[PubMed:29795347]
[PMC:PMC5980784]
Related Antibodies: LS-B6516.
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RTN4 / Nogo Rabbit anti-Human Polyclonal (aa14-30) Antibody
Mouse, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
RTN4 / Nogo Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
RTN4 / Nogo Goat anti-Human Polyclonal (aa501-515) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$440
RTN4 / Nogo Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$564
RTN4 / Nogo Rabbit-New Zealand White anti-Human Polyclonal (aa1050-1100) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$393
RTN4 / Nogo Rabbit anti-Human Polyclonal (Glu499) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
RTN4 / Nogo Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
RTN4 / Nogo Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, WB
Unconjugated
100 µg/$832
E. coli
GST, N-terminus
SDS-PAGE
Biologically active
The recombinant human RTN4/GST chimera consists of 417 amino acids and has a predicted molecular mass of 46.2 kDa. It migrates as an approxiamtely 48 kDa band in SDS-PAGE under reducing conditions.
100 µg/$441
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
RTN4 / Nogo Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$351
RTN4 / Nogo Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$341
Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
RTN4 / Nogo Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
RTN4 / Nogo Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
RTN4 / Nogo Rabbit anti-Human Polyclonal (aa450-499) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
RTN4 / Nogo Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$299
RTN4 / Nogo Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RTN4 / Nogo Rabbit anti-Human Polyclonal (aa460-510) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
RTN4 / Nogo Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
RTN4 / Nogo Sheep anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µg/$930
RTN4 / Nogo Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
RTN4 / Nogo Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$832
RTN4 / Nogo Rat anti-Mouse Monoclonal (aa1-183) (11n137) Antibody
Mouse
IHC
Unconjugated
100 µg/$872
RTN4 / Nogo Sheep anti-Human Polyclonal (aa1-200) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$930
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