Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
RTN4 / Nogo antibody was raised against synthetic peptide derived from the internal region of rat Nogo-A (Reticulon 4-A, Foocen, Glut4 Vesicle 20kD Protein), which differs from the human sequence by only one amino acid.
Specific for rat Nogo-A. On Western blots for rat brain homogenates, it identifies a band at ~190kD. The faint bands at lower molecular weights may represent the deglycosylated form (s) or degradation product (s) of rat Nogo-A. Reactivity has been confirmed with rat brain homogenates. Based on amino acid sequence homolog, cross-reactivity with human is expected.
Suitable for use in Western Blot and Immunoprecipitation. Western Blot: 0.5-2 ug/ml. Immunoprecipitation: 7 ug/Reaction.
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity).