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Human RTN1 / Reticulon 1 | |
Mouse | |
Human, Rat, Pig (tested or 100% immunogen sequence identity) | |
IgG1 Monoclonal [RNL-4] | |
Unconjugated | |
Purified | |
Unmodified |
Synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C | |
Recognizes an epitope located within the first 20 amino acids of Reticulon-1C (NSP-C). Reacts with peripheral nerves and ganglia of various tissues and cross-reacts with smooth muscle cells and myoepithelium. In the central nervous system it reacts with the neurohypophysis and pars intermedia of the pituitary gland, and a weak diffuse staining was observed in neurons of the granular and molecular layer of the cerebellar cortex, while glial cells, cerebellar medulla and Purkinje cells are negative. Reticulon-1 has been found to indicate neuronal differentiation and to be downregulated in neurological pathologies. |
PBS containing 0.09% sodium azide | |
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. | |
For research use only. |
RTN1 Antibody, Reticulon-1 Antibody, NSP Antibody, Reticulon 1 Antibody
RTN1 / Reticulon 1 belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants.
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