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Anti-RTN1 / Reticulon 1 Antibody (clone RNL-4) LS-C146788

Catalog	Size	Price
LS-C146788-100	100 µg	Unavailable

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Application:	IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
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Anti-RTN1 / Reticulon 1 Antibody LS-C50929

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Immunohistochemistry on frozen section of swine brain

Anti-RTN1 / Reticulon 1 Antibody (clone RNL-2) IHC-plus™ LS-B7188

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Anti-RTN1 / Reticulon 1 Antibody (aa198-227) LS-C158904

Antibody:	Rabbit Polyclonal to Human RTN1 / Reticulon 1
Reactivity:	Human, Mouse
Application:	Western blot
Format:	Unconjugated

RTN1 Antibody western blot of mouse testis tissue lysates (35 ug/lane). The RTN1 antibody detected the RTN1 protein (arrow).

Antibody:	Mouse Monoclonal [clone RNL-4] (IgG1) to Human RTN1 / Reticulon 1
Reactivity:	Human, Rat, Pig
Application:	IHC, IHC - Frozen, ICC, Western blot, Flow Cytometry
Format:	Unconjugated

Immunoblotting of RNL-4 recognizing NSP-C Reticulon 1-C (23 kDa) in extract from neuroblastoma cell line LA-N-5

Details

Target:	Human RTN1 / Reticulon 1
Host:	Mouse
Reactivity:	Human, Rat, Pig (tested or 100% immunogen sequence identity)
Clonality:	IgG1 Monoclonal [RNL-4]
Conjugations:	Unconjugated
Purification:	Purified
Modifications:	Unmodified

Applications

Approved:

IHC
IHC - Frozen (1:50 - 1:100)
ICC
Western blot (1:100 - 1:500)
Flow Cytometry (1:50 - 1:100)

Failed:

IHC - Paraffin

Specificity and Use

Immunogen:

Synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C

Specificity:

Recognizes an epitope located within the first 20 amino acids of Reticulon-1C (NSP-C). Reacts with peripheral nerves and ganglia of various tissues and cross-reacts with smooth muscle cells and myoepithelium. In the central nervous system it reacts with the neurohypophysis and pars intermedia of the pituitary gland, and a weak diffuse staining was observed in neurons of the granular and molecular layer of the cerebellar cortex, while glial cells, cerebellar medulla and Purkinje cells are negative. Reticulon-1 has been found to indicate neuronal differentiation and to be downregulated in neurological pathologies.

Packaging

Presentation:	PBS containing 0.09% sodium azide
Storage:	Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Restrictions:	For research use only.

About RTN1 / Reticulon 1

Uniprot: Q16799 NCBI: NM_021136 NP_066959.1

Synonyms: RTN1 Antibody, Reticulon-1 Antibody, NSP Antibody, Reticulon 1 Antibody

Description: RTN1 / Reticulon 1 belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants.

(More About RTN1 / Reticulon 1)

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Western blot

Immunoblotting of RNL-4 recognizing NSP-C Reticulon 1-C (23 kDa) in extract from neuroblastoma cell line LA-N-5

Requested From:
Date Requested: 4/24/2018

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