RTF1

Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex.

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Products

Antibodies (16)

Proteins (5)

Type

Over-Expression Lysate (4)

Primary (16)

Recombinant (1)

Target

RTF1 (21)

Reactivity

Human (16)

Mouse (2)

Application

IHC (4)

IHC-P (1)

WB (12)

ELISA (11)

IF (2)

IP (2)

Host

rabbit (16)

Isotype

IgG (15)

Clonality

polyclonal pc (16)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (8)

Epitope

aa482-510 (7)

C-Terminus (2)

aa300-350 (1)

aa620-670 (1)

Publications

No (21)

Tag

GST (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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RTF1 Antibody LS-C679376

Antibody:

RTF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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RTF1 Antibody (HRP) LS-C679375

Antibody:

RTF1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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RTF1 Antibody (Biotin) LS-C679378

Antibody:

RTF1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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RTF1 Antibody (FITC) LS-C679374

Antibody:

RTF1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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RTF1 Antibody (aa300-350) LS-C287101

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa300-350) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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RTF1 Antibody (C-Terminus) LS-C286519

Antibody:

RTF1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

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RTF1 Antibody LS-C753847

Antibody:

RTF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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RTF1 Antibody (C-Terminus) LS-C288139

Antibody:

RTF1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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RTF1 Antibody (aa482-510) LS-C324856

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa482-510) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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RTF1 Antibody (aa482-510, Biotin) LS-C223975

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa482-510) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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RTF1 Antibody (aa482-510, FITC) LS-C223976

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa482-510) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

RTF1 Antibody (aa482-510, Azide-free, HRP) LS-C223977

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa482-510) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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RTF1 Antibody (aa482-510, APC) LS-C223974

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa482-510) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

RTF1 Antibody (aa482-510, PE) LS-C223978

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa482-510) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

RTF1 Antibody (aa620-670) LS-C287102

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa620-670) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

RTF1 Antibody (aa482-510) LS-C162800

Antibody:

RTF1 Rabbit anti-Human Polyclonal (aa482-510) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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Human RTF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87504

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.1 kDa

Price:

20 µg/$215

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Human RTF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87505

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67 kDa

Price:

20 µg/$150

Select

Human RTF1 Protein (Recombinant GST) (Full Length) - LS-G32748

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

93.6 kDa

Price:

10 µg/$479; 25 µg/$670

Select

RTF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129099

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.1 kDa

Price:

100 µg/$710

Select

RTF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113442

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67 kDa

Price:

100 µg/$494

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