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Anti-RPE65 Antibody IHC-plus™ LS-B90

Note: This antibody replaces LS-C2878


Wt. Vol. Conc. Price
- 100 µl 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Alternate Forms of this Antibody

LS-C83723 Biotin Conjugated
LS-C141118 DY650 Conjugated
LS-C141119 DY488 Conjugated
LS-C141120 DY550 Conjugated

Most Popular RPE65 Antibodies

Anti-RPE65 Antibody IHC-plus™ LS-B90
Mouse Monoclonal (IgG1,k) to Bovine RPE65
Bovine, Human, Mouse, Rat, Dog, Pig, Chicken
IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Immunohistochemistry Image
Anti-RPE65 Antibody LS-C75428
Mouse Monoclonal (IgG1,k) to Bovine RPE65
Bovine, Human, Mouse
IHC - Frozen, ICC, Immunofluorescence, Western blot, ELISA
Anti-RPE65 Antibody (clone 401.8B11.3D9, DY488) LS-C141119
Mouse Monoclonal [clone 401.8B11.3D9] (IgG1,k) to Bovine RPE65
Bovine, Human, Mouse, Pig
IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
DY488 Conjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (1)
Mouse Monoclonal (IgG1,k) to Bovine RPE65
Bovine, Human, Mouse, Rat, Dog, Pig, Chicken
IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry (applications tested for the base form of this product only)


Bovine RPE65
Bovine, Human, Mouse, Rat, Dog, Pig, Chicken (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal
Protein A purified


  • IHC - Paraffin (2.5 µg/ml)
  • IHC - Frozen (1:250)
  • ICC
  • Western blot (1:5000 - 1:10000)
  • Flow Cytometry
  • (applications tested for the base form of this product only)

Specificity and Use

RPE65 antibody was raised against bovine RPE microsomal membrane proteins
Immunohistochemistry: LS-B90 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B90 was determined to be 2.5 ug/ml.


PBS, 0.05% sodium azide.
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
For research use only.

Publications (1)

Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair. Machali[Character 144]ska A, Kawa MP, Pius-Sadowska E, Rogi[Character 144]ska D, K[Character 142]os P, Baumert B, Wiszniewska B, Machali[Character 144]ski B. Experimental eye research. 2013 Jul;112:68-78. [Full Text Article] [PubMed:23623997]

About RPE65

Q16518 NM_000329 NP_000320.1

RPE65 Antibody, LCA2 Antibody, RBP-binding membrane protein Antibody, Retinol isomerase Antibody, SRPE65 Antibody, Rd12 Antibody, MRPE65 Antibody, Retinoid isomerohydrolase Antibody, RP20 Antibody

Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT.


Anti-RPE65 antibody IHC of human brain cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B90 concentration 5 ug/ml. This image was taken for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.

Requested From: United States
Date Requested: 10/23/2016

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