Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone G28-8] (IgG1) to Human RP105 / CD180
Rat Monoclonal (IgG2a) to Mouse RP105 / CD180
Flow Cytometry, Functional Assay
Mouse RP105 / CD180
Mouse (tested or 100% immunogen sequence identity)
Flow Cytometry (1:50)
Specificity and Use
Recognizes mouse Radioprotective 105.
Can be used for Flow Cytometry and B cell activation in functional studies. Flow Cytometry: 1:50. Before use in biological assays, the product must be filter sterilized and depending on the concentration to be used dialyzed against culture medium to remove the sodium azide added. Please inquire for availability of azide free solutions.
PBS, 0.02% sodium azide, 0.1% BSA.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.