Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone G28-8] (IgG1) to Human RP105 / CD180
Mouse Monoclonal [clone MHR73] (IgG1) to Human RP105 / CD180
IHC - Frozen, Immunoprecipitation, Flow Cytometry
Human RP105 / CD180
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MHR73]
IHC - Frozen
Specificity and Use
RP105 / CD180 antibody was raised against m12HRP cell line.
Recognizes human CD180 (RP105) a 105kD type 1 transmembrane protein, which belongs to the toll-like receptor family. CD180 is primarily expressed in mature peripheral B cells and is thought to play a role in the innate immune response to bacterial lipopolysaccharide, through cooperation with MD-1 and TLR4.
0.09% sodium azide
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.