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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RP105 / CD180 Antibody (clone G28‑8) LS‑C204304
CD180 antibody LS-C204304 is an unconjugated mouse monoclonal antibody to human CD180 (RP105). Validated for Flow, Func and IP.
100 µg (1 mg/ml)

Popular RP105 / CD180 Products

Anti-CD180 / RP105 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2693 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Species: Human
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Surface staining of normal human peripheral blood cells with anti-human CD180 (MHR73-11) PE. Appropriate isotype controls were used (open histogram). Cells in the lymphocyte population were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: Flow Cytometry
Immunohistochemistry of RP105 in human spleen tissue withRP105 antibody at 10 ug/ml.
Species: Human, Mouse
Applications: IHC, Western blot
Surface staining of human peripheral blood cells with anti-CD180 (G28-8) APC.
Species: Human
Applications: Immunoprecipitation, Flow Cytometry, Functional Assay

Product Description

CD180 antibody LS-C204304 is an unconjugated mouse monoclonal antibody to human CD180 (RP105). Validated for Flow, Func and IP.
About RP105 / CD180
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. Q99467 NM_005582 NP_005573.2

CD180 Antibody, CD180 antigen Antibody, Lymphocyte antigen 64 Antibody, Ly78 Antibody, LY64 Antibody, CD180 molecule Antibody, RP105 Antibody


Human RP105 / CD180
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [G28-8]
Unconjugated. Also available conjugated with APC, PE.
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
  • Immunoprecipitation
  • Flow Cytometry
  • Functional Assay
  • (applications tested for the base form of this product only)
RP105 / CD180 antibody was raised against human tonsillar B cells
The mouse monoclonal antibody G28-8 recognizes CD180, a 95-105 kDa TLR-like glycoprotein expressed on peripheral blood monocytes and dendritic cells, mantle zone B cells and marginal zone B cells, but very weakly on germinal center B cells.
Flow Cytometry: Recommended dilution - 2 ug/ml. Functional Application: induction of B cell proliferation.
PBS, pH 7.4, 15 mM Sodium Azide
Store at 2°C to 8°C. Do not freeze.
For research use only.

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Requested From: United States
Date Requested: 9/23/2018

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