ROBO3

roundabout, axon guidance receptor, homolog 3 (Drosophila)

ROBO3 is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

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Antibodies (17)

ELISA Kits (1)

Proteins (1)

Type

Primary (17)

Recombinant (1)

Sandwich (1)

Target

ROBO3 (19)

Reactivity

Human (14)

Mouse (6)

Rat (2)

Monkey (1)

Rabbit (1)

Application

IHC (3)

IHC-P (3)

WB (11)

Flo (1)

ELISA (4)

Peptide-ELISA (5)

Host

rabbit (12)

goat (5)

Isotype

IgG (7)

Clonality

polyclonal pc (17)

Format

96-Well Microplate (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (14)

Epitope

C-Terminus (4)

aa1303-1316 (1)

aa1338-1351 (1)

aa201-213 (1)

aa914-926 (1)

aa915-926 (1)

Publications

No (18)

Yes (1)

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Cell Culture Supernatants (1)

Plasma (1)

Serum (1)

Tag

GST (1)

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Human (1)

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Wheat Germ Extract (1)

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Purified (1)

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ROBO3 Antibody (C-Terminus) LS-C345713

(4.0) Rating

(1) Publication(s)

Antibody:

ROBO3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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ROBO3 Antibody (C-Terminus, HRP) LS-C480501

Antibody:

ROBO3 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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ROBO3 Antibody (C-Terminus, Biotin) LS-C480499

Antibody:

ROBO3 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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ROBO3 Antibody (C-Terminus, FITC) LS-C480500

Antibody:

ROBO3 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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ROBO3 Antibody (aa201-213) LS-C139697

Antibody:

ROBO3 Goat anti-Human Polyclonal (aa201-213) Antibody

Reactivity:

Human

Applications:

Flo, Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

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ROBO3 Antibody (aa915-926) LS-C55419

Antibody:

ROBO3 Goat anti-Human Polyclonal (aa915-926) Antibody

Reactivity:

Rabbit, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$467

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ROBO3 Antibody LS-C780440

Antibody:

ROBO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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ROBO3 Antibody LS-C817143

Antibody:

ROBO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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ROBO3 Antibody LS-C660575

Antibody:

ROBO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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ROBO3 Antibody LS-C660574

Antibody:

ROBO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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ROBO3 Antibody LS-C676414

Antibody:

ROBO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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ROBO3 Antibody (aa1303-1316) LS-C742479

Antibody:

ROBO3 Goat anti-Mouse Polyclonal (aa1303-1316) Antibody

Reactivity:

Mouse

Applications:

IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

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ROBO3 Antibody LS-C497999

Antibody:

ROBO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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ROBO3 Antibody (aa914-926) LS-C55418

Antibody:

ROBO3 Goat anti-Mouse Polyclonal (aa914-926) Antibody

Reactivity:

Mouse, Rat

Applications:

Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$401

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ROBO3 Antibody LS-C749902

Antibody:

ROBO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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ROBO3 Antibody (aa1338-1351) LS-C742476

Antibody:

ROBO3 Goat anti-Mouse Polyclonal (aa1338-1351) Antibody

Reactivity:

Mouse

Applications:

Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$401

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ROBO3 Antibody LS-C834252

Antibody:

ROBO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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Human ROBO3 (Sandwich ELISA) ELISA Kit - LS-F50023

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

15 - 0.06 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$672

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Human ROBO3 Protein (Recombinant GST) (Full Length) - LS-G34958

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.91 kDa

Price:

10 µg/$479; 25 µg/$670

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