RNF41

ring finger protein 41

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

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Antibodies (18)

Proteins (10)

Type

Over-Expression Lysate (6)

Primary (18)

Recombinant (4)

Target

RNF41 (28)

Reactivity

Human (18)

Mouse (5)

Rat (4)

Bovine (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Hamster (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (3)

Zebrafish (3)

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Application

IHC (2)

IHC-P (1)

WB (17)

ELISA (9)

ICC (1)

IF (1)

Peptide-ELISA (1)

Host

rabbit (16)

mouse (2)

Isotype

IgG (14)

IgG1 (2)

Clonality

monoclonal mc (2)

polyclonal pc (16)

Clone

OTI2C1 (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

Carrier-free (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (10)

Epitope

aa255-281 (7)

aa74-123 (4)

Publications

No (28)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (7)

Species

Human (7)

Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (2)

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RNF41 Antibody LS-C676409

Antibody:

RNF41 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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RNF41 Antibody LS-C807943

Antibody:

RNF41 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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RNF41 Antibody LS-C817139

Antibody:

RNF41 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

50 µl/$317; 100 µl/$375; 200 µl/$473

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RNF41 Antibody LS-C660564

Antibody:

RNF41 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

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RNF41 Antibody (aa255-281) LS-C324748

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa255-281) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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RNF41 Antibody (aa255-281, Biotin) LS-C240149

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa255-281) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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RNF41 Antibody (aa255-281, FITC) LS-C240150

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa255-281) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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RNF41 Antibody (aa255-281, Azide-free, HRP) LS-C248031

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa255-281) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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RNF41 Antibody (aa255-281, APC) LS-C240148

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa255-281) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

RNF41 Antibody (aa255-281, PE) LS-C240151

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa255-281) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

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RNF41 Antibody LS-C780300

Antibody:

RNF41 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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RNF41 Antibody (clone OTI2C1) LS-C795818

Antibody:

RNF41 Mouse anti-Human Monoclonal (OTI2C1) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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RNF41 Antibody (clone OTI2C1, Carrier-free) LS-C798877

Antibody:

RNF41 Mouse anti-Human Monoclonal (Carrier-free) (OTI2C1) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

RNF41 Antibody (aa74-123) LS-C80101

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa74-123) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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RNF41 Antibody (aa74-123, HRP) LS-C431613

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa74-123) (HRP) Antibody

Reactivity:

Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

RNF41 Antibody (aa74-123, Biotin) LS-C431611

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa74-123) (Biotin) Antibody

Reactivity:

Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

RNF41 Antibody (aa74-123, FITC) LS-C431612

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa74-123) (FITC) Antibody

Reactivity:

Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

RNF41 Antibody (aa255-281) LS-C158878

Antibody:

RNF41 Rabbit anti-Human Polyclonal (aa255-281) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

Human RNF41 Protein (Recombinant GST, N-terminus) (aa218-317) - LS-G61408

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human RNF41 Protein (Recombinant GST, N-terminus) (aa1-317) - LS-G56960

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

Select

Human RNF41 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89424

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.8 kDa

Price:

20 µg/$150

Select

Human RNF41 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89426

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

20 µg/$150

Select

Human RNF41 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89425

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

20 µg/$150

Select

Human RNF41 Protein (Recombinant GST) (Full Length) - LS-G32004

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.3 kDa

Price:

10 µg/$479; 25 µg/$670

Select

RNF41 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103874

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.8 kDa

Price:

100 µg/$494

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