Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Bat, Bovine, Dog, Pig, Rabbit (tested or 100% immunogen sequence identity)
Mouse, Rat, Hamster, Horse (at least 90% immunogen sequence identity)
Western blot (1:32000) & (1 - 3 µg/ml)
Specificity and Use
RNF31 antibody was raised against synthetic peptide C-EEVPLGQSIPRRRK from the C-terminus of human RNF31 (NP_060469.4). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Bovine, Dog, Bat, Rabbit, Pig (100%); Mouse, Rat, Hamster, Horse (93%).
LS-E25414 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C55405. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
RNF31 Antibody, HOIP Antibody, HOIL-1-interacting protein Antibody, Ring finger protein 31 Antibody, ZIBRA Antibody
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation.