RNF168

ring finger protein 168, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

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Products

Antibodies (18)

Proteins (5)

Type

Over-Expression Lysate (2)

Primary (18)

Recombinant (3)

Target

RNF168 (23)

Reactivity

Human (18)

Mouse (5)

Rat (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Hamster (3)

Monkey (3)

Rabbit (3)

Application

IHC (5)

IHC-P (5)

WB (14)

ELISA (9)

IF (1)

Host

rabbit (18)

Isotype

IgG (17)

Clonality

polyclonal pc (18)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (7)

Epitope

aa468-496 (7)

aa401-450 (4)

Publications

No (23)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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RNF168 Antibody (aa401-450) LS-C82462

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa401-450) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$424

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RNF168 Antibody (aa401-450, HRP) LS-C445142

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa401-450) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

RNF168 Antibody (aa401-450, Biotin) LS-C445140

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa401-450) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

RNF168 Antibody (aa401-450, FITC) LS-C445141

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa401-450) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

RNF168 Antibody LS-C660546

Antibody:

RNF168 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

RNF168 Antibody LS-C674478

Antibody:

RNF168 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

RNF168 Antibody (HRP) LS-C674479

Antibody:

RNF168 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

RNF168 Antibody (Biotin) LS-C674480

Antibody:

RNF168 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

RNF168 Antibody (FITC) LS-C674481

Antibody:

RNF168 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

RNF168 Antibody (aa468-496) LS-C324732

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa468-496) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

RNF168 Antibody (aa468-496, Biotin) LS-C240109

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa468-496) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

RNF168 Antibody (aa468-496, FITC) LS-C240110

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa468-496) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

RNF168 Antibody (aa468-496, Azide-free, HRP) LS-C248023

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa468-496) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

RNF168 Antibody (aa468-496, APC) LS-C240107

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa468-496) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

RNF168 Antibody (aa468-496, PE) LS-C240114

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa468-496) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

RNF168 Antibody LS-C108507

Antibody:

RNF168 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$460

Select

RNF168 Antibody (aa468-496) LS-C158871

Antibody:

RNF168 Rabbit anti-Human Polyclonal (aa468-496) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

RNF168 Antibody LS-C796592

Antibody:

RNF168 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$414

Select

Human RNF168 Protein (Recombinant GST, N-terminus) (aa462-571) - LS-G63778

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human RNF168 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93403

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.8 kDa

Price:

20 µg/$150

Select

Human RNF168 Protein (Recombinant GST) (Full Length) - LS-G36876

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

91.4 kDa

Price:

2 µg/$439

Select

RNF168 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106148

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.8 kDa

Price:

100 µg/$494

Select

Human RNF168 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72725

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.8 kDa

Price:

20 µg/$1,107

Viewing 1-23 of 23 product results

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