Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
RNF144B Antibody, BA528A10.3 Antibody, IBRDC2 Antibody, p53RFP Antibody, IBR domain containing 2 Antibody, PIR2 Antibody, Ring finger protein 144B Antibody
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism.
Anti-RNF144B mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RNF144B.
Immunofluorescent staining of HeLa cells using anti-RNF144B mouse monoclonal antibody.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RNF144B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RNF144B.
Flow cytometry of Jurkat cells, using anti-RNF144B antibody, (Red) compared to a nonspecific negative control antibody (Blue).
Flow cytometry of HeLa cells, using anti-RNF144B antibody, (Red) compared to a nonspecific negative control antibody (Blue).
HEK293T cells transfected with either pCMV6-ENTRY RNF144B (Red) or empty vector control plasmid (Blue) were immunostained with anti-RNF144B mouse monoclonal, and then analyzed by flow cytometry.