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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RNF139 / TRC8 Antibody (Internal) LS‑C153494 Best Seller
Antibody
TRC8 antibody LS-C153494 is an unconjugated rabbit polyclonal antibody to s. pombe TRC8 (RNF139). Validated for ELISA, IHC and WB.
Catalog
Size
Price
LS-C153494-100
100 µg (1 mg/ml)
Unavailable

Popular RNF139 / TRC8 Products

Anti-RNF139 / TRC8 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8095 dilution 5-10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot
Anti-RNF139 / TRC8 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8293 dilution 3.75 ug/ml.
Species: Human, Monkey
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
All lanes: Anti-RNF139 Antibody (C-Term) at 1:2000 dilution. Lane 1: Caki-1 whole cell lysate. Lane 2: human brain lysate. Lane 3: human heart lysate. Lane 4: human kidney lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 76 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Species: Human
Applications: Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Immunohistochemistry of paraffin-embedded human kidney tissue at dilution of 1:100
Species: Human
Applications: IHC, ELISA

Product Description

TRC8 antibody LS-C153494 is an unconjugated rabbit polyclonal antibody to s. pombe TRC8 (RNF139). Validated for ELISA, IHC and WB.
About RNF139 / TRC8
E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. Q8WU17 NM_007218 NP_009149.2

RNF139 Antibody, HRCA1 Antibody, RCA1 Antibody, TRC8 Antibody, Ring finger protein 139 Antibody


Specifications

Target
S. pombe RNF139 / TRC8
Host
Rabbit
Reactivity
S. pombe (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC
  • Western blot
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
RNF139 / TRC8 antibody was raised against synthetic peptide derived from internal domain of RCA1 protein of Schizosaccharomyces pombe.
Epitope
Internal
Specificity
Reacts with 85kD RCA1 protein from Schizosaccharomyces pombe.
Presentation
100 mM Tris-glycine, 2% sucrose
Reconstitution
100 µl Distilled water
Storage
Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at 4°C. For extended periods store in aliquots at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/21/2018

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