RNF126

ring finger protein 126

E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

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Products

Antibodies (11)

Proteins (5)

Type

Over-Expression Lysate (4)

Primary (11)

Recombinant (1)

Target

RNF126 (16)

Reactivity

Human (11)

Mouse (6)

Rat (4)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Application

IHC (2)

WB (8)

ELISA (6)

IF (1)

Peptide-ELISA (1)

Host

rabbit (10)

mouse (1)

Isotype

IgG (9)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (10)

Clone

3F11 (1)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (5)

Epitope

aa71-120 (4)

aa39-225 (1)

aa84-115 (1)

Publications

No (16)

Tag

GST (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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RNF126 Antibody (aa39-225) LS-C499668

Antibody:

RNF126 Rabbit anti-Human Polyclonal (aa39-225) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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RNF126 Antibody (HRP) LS-C499671

Antibody:

RNF126 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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RNF126 Antibody (Biotin) LS-C499670

Antibody:

RNF126 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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RNF126 Antibody (FITC) LS-C499675

Antibody:

RNF126 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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RNF126 Antibody LS-C402533

Antibody:

RNF126 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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RNF126 Antibody (clone 3F11) LS-C139236

Antibody:

RNF126 Mouse anti-Human Monoclonal (3F11) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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RNF126 Antibody (aa84-115) LS-C393007

Antibody:

RNF126 Rabbit anti-Human Polyclonal (aa84-115) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

RNF126 Antibody (aa71-120) LS-C102009

Antibody:

RNF126 Rabbit anti-Human Polyclonal (aa71-120) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

RNF126 Antibody (aa71-120, HRP) LS-C444849

Antibody:

RNF126 Rabbit anti-Human Polyclonal (aa71-120) (HRP) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Rat, Chimpanzee, Gibbon, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

RNF126 Antibody (aa71-120, Biotin) LS-C444847

Antibody:

RNF126 Rabbit anti-Human Polyclonal (aa71-120) (Biotin) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Rat, Chimpanzee, Gibbon, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

RNF126 Antibody (aa71-120, FITC) LS-C444848

Antibody:

RNF126 Rabbit anti-Human Polyclonal (aa71-120) (FITC) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Rat, Chimpanzee, Gibbon, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

Human RNF126 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85741

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.7 kDa

Price:

20 µg/$150

Select

Human RNF126 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85740

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36 kDa

Price:

20 µg/$150

Select

Human RNF126 Protein (Recombinant GST) (Full Length) - LS-G34375

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.6 kDa

Price:

10 µg/$479; 25 µg/$670

Select

RNF126 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103910

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.7 kDa

Price:

100 µg/$494

Select

RNF126 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112174

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36 kDa

Price:

100 µg/$494

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