Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
RNASEL / RNase L
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.
| Gene Name: | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) |
| Family/Subfamily: | Protein Kinase , Provisional Protein Kinase |
| Synonyms: | RNASEL, 2-5A-dependent ribonuclease, 2-5A-dependent RNAase, 2-5A-dependent RNase, HPC1, PRCA1, RNS4, RNase L, Prostate cancer 1, Ribonuclease 4, Ribonuclease L |
| Target Sequences: | NM_021133 NP_066956.1 Q05823 |
Publications (8)
1
2-5A-dependent RNase molecules dimerize during activation by 2-5A. Dong B, Silverman RH. The Journal of biological chemistry. 1995 270:4133-7.
[PubMed:7876164]
2
A bipartite model of 2-5A-dependent RNase L. Dong B, Silverman RH. The Journal of biological chemistry. 1997 272:22236-42. (WB; Human)
[PubMed:9268370]
3
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis. Wang L, Zhou A, Vasavada S, Dong B, Nie H, Church JM, Williams BR, Banerjee S, Silverman RH. Clinical cancer research : an official journal of the American Association for Cancer Research. 1995 1:1421-8.
[PubMed:9815940]
☰ Filters
Products
Antibodies
(33)
Proteins
(5)
ELISA Kits
(1)
Type
Over-Expression Lysate
(2)
Primary
(33)
Recombinant
(3)
Sandwich
(1)
Target
RNASEL / RNase L
(39)
Reactivity
Human
(27)
Mouse
(9)
Rat
(2)
Gibbon
(3)
Hamster
(1)
Horse
(3)
Monkey
(3)
Orangutan
(3)
Pig
(3)
Primate
(5)
Application
IHC
(8)
IHC-P
(5)
WB
(32)
ELISA
(16)
Host
rabbit
(27)
mouse
(6)
Product Group
IHCPlus
(1)
Isotype
IgG
(17)
IgG1,k
(6)
Clonality
monoclonal mc
(6)
polyclonal pc
(27)
Clone
2E9
(5)
3B4
(1)
Format
96-Well Strip Plate
(1)
APC
(1)
APC Conjugated
(2)
Azide-free
(1)
Biotin Conjugated
(5)
Cy3 Conjugated
(1)
Cy7 Conjugated
(1)
DY488 Conjugated
(1)
DY550 Conjugated
(1)
DY650 Conjugated
(1)
FITC Conjugated
(4)
HRP Conjugated
(4)
PE Conjugated
(2)
Unconjugated
(11)
Epitope
aa358-583
(8)
aa140-167
(7)
C-Terminus
(4)
Publications
No
(39)
Sample Type
Plasma
(1)
Serum
(1)
Tissue Homogenates
(1)
Tag
GST, N-terminus
(1)
His
(1)
His, N-Terminal
(1)
Myc-DDK (Flag)
(2)
Species
Human
(4)
Source
293T Cells
(1)
E. coli
(2)
HEK 293 Cells
(1)
Wheat Germ Extract
(1)
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) Antibody
Mouse
WB
Unconjugated
400 µl/$393
RNASEL / RNase L Mouse anti-Human Monoclonal (2E9) Antibody
Hamster, Primate, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
RNASEL / RNase L Mouse anti-Human Monoclonal (Biotin) (2E9) Antibody
Human, Primate
ELISA, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
RNASEL / RNase L Mouse anti-Human Monoclonal (DY650) (2E9) Antibody
Human, Primate
ELISA, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
RNASEL / RNase L Mouse anti-Human Monoclonal (DY550) (2E9) Antibody
Human, Primate
ELISA, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
RNASEL / RNase L Mouse anti-Human Monoclonal (DY488) (2E9) Antibody
Human, Primate
ELISA, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
HEK 293 Cells
Myc-DDK (Flag)
83.4 kDa
100 µg/$710
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
RNASEL / RNase L Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
RNASEL / RNase L Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
RNASEL / RNase L Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
RNASEL / RNase L Mouse anti-Human Monoclonal (3B4) Antibody
Human
ELISA
Unconjugated
100 µg/$423
RNASEL / RNase L Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
RNASEL / RNase L Rabbit anti-Human Polyclonal (aa358-583) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
Viewing 1-25
of 39
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
