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Anti-RIPK3 / RIP3 Antibody (aa473-486) LS-C380

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $345
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
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Rabbit Polyclonal to Mouse RIPK3 / RIP3
Mouse
Western blot
Unconjugated

Details

Mouse RIPK3 / RIP3
Rabbit
Polyclonal
Immunoaffinity purified

Applications

Western blot (0.5 - 1 µg/ml)
IHC

Specificity and Use

RIPK3 / RIP3 antibody was raised against synthetic peptide from mouse RIPK3 / RIP3.
aa473-486
peptide (aqfgrgrgwqpfhk) corresponding to amino acids 473 to 486 of murine RIP3

Packaging

Phosphate buffered saline, containing 0.02% sodium azide
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About RIPK3 / RIP3

Q9Y572 NM_006871 NP_006862.2

RIPK3 Antibody, Receptor interacting protein 3 Antibody, RIP-like protein kinase 3 Antibody, RIP3 Antibody, RIP-3 Antibody, Receptor-interacting protein 3 Antibody

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Western blot

Western blot
Western blot analysis of RIP3 in mouse 3T3 whole cell lysate in the absence (A) or presence (B) of blocking peptide with RIP3 antibody at 1 µg /ml.
 

Requested From: United States
Date Requested: 9/30/2016

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