RIPK1 / RIP

receptor (TNFRSF)-interacting serine-threonine kinase 1

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

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Products

Antibodies (60)

Proteins (8)

ELISA Kits (6)

Type

Over-Expression Lysate (1)

Primary (60)

Recombinant (7)

Sandwich (6)

Target

RIPK1 / RIP (74)

Reactivity

Human (49)

Mouse (7)

Rat (12)

Bovine (3)

Dog (6)

Gibbon (3)

Horse (3)

Monkey (4)

Application

IHC (17)

IHC-Fr (1)

IHC-P (7)

WB (51)

ELISA (17)

IF (2)

IP (4)

Peptide-ELISA (1)

Host

rabbit (47)

mouse (13)

Product Group

IHCPlus (4)

Isotype

IgG (26)

IgG1 (8)

IgG2a (4)

IgG2b (1)

Clonality

monoclonal mc (13)

polyclonal pc (47)

Clone

2G3 (2)

OTI1A7 (2)

OTI2A8 (2)

OTI2D6 (2)

OTI2F1 (2)

OTI2F4 (2)

Format

96-Well Strip Plate (6)

APC (2)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (6)

Carrier-free (6)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (3)

Preservative Free (1)

Unconjugated (32)

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Epitope

aa1-179 (8)

aa17-289 (8)

aa133-422 (7)

aa152-180 (7)

aa411-460 (4)

aa1-430 (1)

aa269-287 (1)

aa316-671 (1)

aa350-400 (1)

aa411-425 (1)

Publications

No (73)

Yes (1)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (3)

Plasma (5)

Serum (5)

Tissue Homogenates (4)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His-SUMOstar, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (2)

Myc-DDK (Flag) (1)

Species

Human (5)

Mouse (1)

Rat (1)

Source

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (3)

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IHC-plus™ RIPK1 / RIP Antibody LS-B4613

(4.0) Rating

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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RIPK1 / RIP Antibody (aa269-287) LS-C147991

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal (aa269-287) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$386

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Mouse RIPK1 / RIP Protein (Recombinant 6His-SUMOstar, N-terminus) (aa1-656) - LS-G57319

Source:

Yeast

Tag:

6His-SUMOstar, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Mouse RIPK1 / RIP (Sandwich ELISA) ELISA Kit - LS-F65172

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human RIPK1 / RIP Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G137344

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

49.4 kDa

Price:

20 µg/$405; 1 mg/$1,679; 100 µg/$598

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Human RIPK1 / RIP (Sandwich ELISA) ELISA Kit - LS-F9254

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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IHC-plus™ RIPK1 / RIP Antibody LS-B4701

(4.0) Rating

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

0.05 mg/$460

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RIPK1 / RIP Antibody (aa411-425) LS-C313178

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal (aa411-425) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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RIPK1 / RIP Antibody (aa17-289, Biotin) LS-C423612

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal (aa17-289) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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IHC-plus™ RIPK1 / RIP Antibody (clone 2G3) LS-B11088

(4.0) Rating

Antibody:

RIPK1 / RIP Mouse anti-Human Monoclonal (2G3) Antibody

Reactivity:

Dog, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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RIPK1 / RIP Antibody (Preservative Free) LS-C815182

Antibody:

RIPK1 / RIP Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody

Reactivity:

Mouse

Applications:

IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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RIPK1 / RIP Antibody (aa411-460) LS-C29834

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal (aa411-460) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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RIPK1 / RIP Antibody LS-C754747

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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IHC-plus™ RIPK1 / RIP Antibody (aa152-180) LS-B12799

(4.0) Rating

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal (aa152-180) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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RIPK1 / RIP Antibody (clone OTI2D6) LS-C175237

Antibody:

RIPK1 / RIP Mouse anti-Human Monoclonal (OTI2D6) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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RIPK1 / RIP Antibody (aa133-422, clone OTI2D6, Carrier-free) LS-C788739

Antibody:

RIPK1 / RIP Mouse anti-Human Monoclonal (aa133-422) (Carrier-free) (OTI2D6) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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Human RIPK1 / RIP Protein (Recombinant GST) (Full Length) - LS-G31304

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

100.3 kDa

Price:

2 µg/$439

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Human RIPK1 / RIP Protein (Recombinant His-T7) (aa17-289) - LS-G25489

Source:

E. coli

Tag:

His-T7

Molecular Weight:

34.9 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Rat RIPK1 / RIP Protein (Recombinant His-T7) (aa1-179) - LS-G25490

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.3 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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RIPK1 / RIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100135

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.8 kDa

Price:

100 µg/$710

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RIPK1 / RIP Antibody (aa152-180) LS-C330061

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal (aa152-180) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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RIPK1 / RIP Antibody (aa152-180, Biotin) LS-C268285

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal (aa152-180) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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RIPK1 / RIP Antibody (aa152-180, APC) LS-C268283

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal (aa152-180) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• APC

• Unconjugated
• Biotin
• APC

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RIPK1 / RIP Antibody (aa133-422, clone 2G3, Carrier-free) LS-C788743

Antibody:

RIPK1 / RIP Mouse anti-Human Monoclonal (aa133-422) (Carrier-free) (2G3) Antibody

Reactivity:

Dog, Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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RIPK1 / RIP Antibody LS-C830300

Antibody:

RIPK1 / RIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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