Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ANKRD3 belongs to the RIP subfamily of kinases. ANKRD3 encodes a deduced 784-amino acid protein with a calculated molecular mass of 86 kD. The protein contains 12 subdomains in the N-terminal region that are highly conserved in all protein kinases, 10 ankyrin-like repeats, and a potential nuclear localization signal. ANKRD3 shares 49% sequence similarity with DAP, but lacks the death domain and the calmodulin-binding domain.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
ANKRD3 Antibody (Q817) western blot of A549 cell line lysates (35 ug/lane). The ANKRD3 antibody detected the ANKRD3 protein (arrow).
Western blot of anti-ANKRD3-Q817 antibody in mouse kidney tissue lysate (35 ug/lane). ANKRD3-Q817(arrow) was detected using the purified antibody.