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Anti-RCAN1 / DSCR1 Antibody (aa145-157) LS-C154834

Ordering

Wt. Vol. Conc. Price
100 µg - 0.5 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular RCAN1 / DSCR1 Antibodies

Anti-RCAN1 / DSCR1 Antibody (aa180-229) LS-C101696
Rabbit Polyclonal (IgG) to Human RCAN1 / DSCR1
Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Sheep
Western blot
Unconjugated
Western blot Image
Anti-RCAN1 / DSCR1 Antibody (aa40-90) LS-C143371
Rabbit Polyclonal to Human RCAN1 / DSCR1
Human, Mouse
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-RCAN1 / DSCR1 Antibody (aa145-157) LS-C154834
Goat Polyclonal to Human RCAN1 / DSCR1
Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit, Sheep, Chicken
Western blot, ELISA
Unconjugated
Western blot Image

100% Guaranteed 100% Guaranteed
Goat Polyclonal to Human RCAN1 / DSCR1
Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit, Sheep, Chicken
Western blot, ELISA
Unconjugated

Details

Human RCAN1 / DSCR1
Goat
Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit, Sheep, Chicken (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • Western blot (1 - 3 µg/ml)
  • ELISA (1:32000)

Specificity and Use

RCAN1 / DSCR1 antibody was raised against synthetic peptide C-HIGSSHLAPPNPD from an internal region of human RCAN1 (NP_004405.3; NP_981962.1; NP_981963.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Sheep, Dog, Bovine, Hamster, Elephant, Panda, Horse, Rabbit, Porcine, Guinea pig, Turkey, Chicken (100%); Platypus (92%); Xenopus (85%).
LS-E27598 - Lyophilized - 100 µg - $145.00
aa145-157
Human RCAN1. This antibody is expected to recognize all three reported isoforms (NP_004405.3; NP_981962.1; NP_981963.1).
Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx 40kD band corresponding to isoform 1L observed in Mouse Brain lysates and this band is not present in the KO mouse. Additional bands around 55kD were consistently observed, however these band were also observed in the KO mice and therefore they represent non-specific signal. We call for caution when used for other assays than Western blot. Data kindly provided by Dana Crawford, PhD, Albany Medical College, NY, USA. Recommended concentration: 1-3 ug/ml.

Packaging

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Store at -20°C. Minimize freezing and thawing.
For research use only.

About RCAN1 / DSCR1

P53805 NM_004414 NP_004405.3

RCAN1 Antibody, ADAPT78 Antibody, DSCR1 Antibody, MCIP1 Antibody, Regulator of calcineurin 1 Antibody, Calcipressin-1 Antibody, CSP1 Antibody, Near DSCR proline-rich protein Antibody

RCAN1 / DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants.

Western blot

Western blot
RCAN1 antibody (1 ug/ml) staining of Mouse Brain and KO Mouse Brain lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
 

Requested From: United States
Date Requested: 12/10/2016

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