Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Monkey, Dog (at least 90% immunogen sequence identity)
Western blot (1:64000) & (1.5 µg/ml)
Specificity and Use
Synthetic peptide C-ELKHTLAKQKGGTD from the C-terminus of human ZFYVE20 / Rabenosyn 5 (NP_071735.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Elephant, Panda, Dog (93%); Bat (86%).
LS-E25583 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C55352. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
RBSN Antibody, 110 kDa protein Antibody, Rabenosyn-5 Antibody, ZFYVE20 Antibody
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).