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RBPJ

recombination signal binding protein for immunoglobulin kappa J region

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.

Gene Name: recombination signal binding protein for immunoglobulin kappa J region
Synonyms: RBPJ, AOS3, CBF1, Csl, KBF2, H-2K binding factor-2, RBP-JK, SUH, Suppressor of hairless homolog, RBP-J, RBP-J kappa, RBPJK, RBPSUH, CBF-1, IGKJRB, IGKJRB1
Target Sequences: NM_015874 NP_056958.3 Q06330

Publications (1)

1
RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. Xie Q, Wu Q, Kim L, Miller TE, Liau BB, Mack SC, Yang K, Factor DC, Fang X, Huang Z, Zhou W, Alazem K, Wang X, Bernstein BE, Bao S, Rich JN. The Journal of clinical investigation. 2016 126:2757-72. (WB; Human) [Full Text Article] [PubMed:27322055] [PMC:PMC4922685] Related Antibodies: LS-C158830.

☰ Filters
Antibodies (37)
Proteins (12)
Over-Expression Lysate (7)
Primary (37)
Recombinant (5)
RBPJ (49)
Human (36)
Mouse (11)
Rat (11)
Bat (3)
Bovine (6)
Chimpanzee (6)
Dog (3)
Gibbon (3)
Guinea pig (6)
Hamster (3)
Horse (6)
Monkey (4)
Orangutan (3)
Pig (3)
Rabbit (6)
Xenopus (3)
IHC (18)
IHC-P (7)
WB (34)
ELISA (15)
ICC (2)
IF (5)
Peptide-ELISA (1)
rabbit (27)
mouse (9)
goat (1)
Product Group
IHCPlus (1)
IgG (21)
IgG1 (8)
IgG2b,k (1)
monoclonal mc (9)
polyclonal pc (28)
4E12 (1)
OTI4B11 (2)
OTI4G10 (2)
OTI6G5 (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (4)
Carrier-free (3)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (23)
aa1-29 (7)
aa1-243 (6)
C-Terminus (4)
aa331-380 (4)
aa208-500 (1)
aa258-500 (1)
No (48)
Yes (1)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (9)
Human (9)
293T Cells (4)
E. coli (1)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (1)
RBPJ Antibody - RBPJ Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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RBPJ Rabbit anti-Human Polyclonal (aa1-29) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
RBPJ Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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RBPJ Rabbit anti-Mouse Polyclonal (aa331-380) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
100 µl/$485
RBPJ Antibody - Immunohistochemistry of paraffin-embedded human pancreatic tissue at dilution of 1:100
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RBPJ Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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RBPJ Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
50 µg/$558
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RBPJ Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
RBPJ Antibody - Immunohistochemistry of paraffin-embedded Human gastric tissue.
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RBPJ Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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RBPJ Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
RBPJ Antibody - RBPJ antibody ARP31121_P050-NP_976028-RBPSUH Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RBPJ Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
RBPJ Antibody - RBPJ antibody ARP31121_P050-NP_976028-RBPSUH Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RBPJ Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Xenopus, Rat, Hamster, Rabbit, Dog, Guinea pig, Bovine, Bat, Horse, Gibbon, Human, Monkey, Chimpanzee, Orangutan
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
RBPJ Antibody - RBPJ antibody ARP31121_P050-NP_976028-RBPSUH Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RBPJ Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Xenopus, Rat, Hamster, Rabbit, Dog, Guinea pig, Bovine, Bat, Horse, Gibbon, Human, Monkey, Chimpanzee, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
RBPJ Antibody - RBPJ antibody ARP31121_P050-NP_976028-RBPSUH Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RBPJ Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Xenopus, Rat, Hamster, Rabbit, Dog, Guinea pig, Bovine, Bat, Horse, Gibbon, Human, Monkey, Chimpanzee, Orangutan
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Select
RBPJ Rabbit anti-Human Polyclonal (aa1-29) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
RBPJ Rabbit anti-Human Polyclonal (aa1-29) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
RBPJ Rabbit anti-Human Polyclonal (aa1-29) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
RBPJ Rabbit anti-Human Polyclonal (aa1-29) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
RBPJ Rabbit anti-Human Polyclonal (aa1-29) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
RBPJ Rabbit anti-Human Polyclonal (aa1-29) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
RBPJ Goat anti-Human Polyclonal (aa208-500) Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µg/$919
RBPJ Antibody - 1:100 staining rat brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RBPJ Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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RBPJ Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
Select
RBPJ Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$361
RBPJ Antibody - RBPJ monoclonal antibody (M01), clone 4E12 Western Blot analysis of RBPJ expression in Jurkat.
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RBPJ Mouse anti-Human Monoclonal (4E12) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$423
RBPJ Antibody - Immunofluorescence of paraformaldehyde-fixed HeLa using RBP-Jkappa antibody at 1:100 dilution.
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RBPJ Rabbit anti-Human Polyclonal (aa258-500) Antibody
Human
ICC, WB
Unconjugated
100 µl/$450
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RBPJ Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
RBPJ Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY RBPJ. (Right lane) cDNA for 48 hrs and lysed
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RBPJ Mouse anti-Human Monoclonal (aa1-243) (OTI4B11) Antibody
Human
WB
Unconjugated
100 µl/$434
Viewing 1-25 of 49 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).