Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse (tested or 100% immunogen sequence identity)
Specificity and Use
RBM39 antibody was raised against the epitope recognized maps to a region between residues 325-375 of human Caper, Coactivator of activating protein-1 and estrogen receptors using the SwissProt entry Q14498 (GeneID 9584).
This antibody is specific for human Caper. Species cross-reactivity: reacts with human protein. Other species have not been tested. Reactivity with mouse Caper is likely owing to conservation between the mouse sequence and the peptide used for this antibody production.
Suitable for use in Western Blot and Immunoprecipitation.
RBM39 is a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X.